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Title:A Dynamic Spectral Light Modulation Unit with Optical Feedback Control for Optogenetic Stimulation
Author(s):Yu, Haichuan
Contributor(s):Boppart, Stephen
Subject(s):optogenetics, neuron, optical, spatial, temporal, feedback, control, light, sculpting, patterning, SLM
Abstract:With recent advances in optical stimulation delivery to optogenetically modified neurons, individual or groups of neurons can be targeted with incredible spatio-temporal accuracy. It is enough to excite the functional neuronal electrophysiology in its native scale, making possible the study of functional neural circuitry. However, excitation of multiple neurons and distinct combinations of neurons within a neuronal circuit with laser optical stimulation has not yet been demonstrated. This work presents an optical feedback control unit that fills this need. The unit synthesizes user input and optical information in a continuous feedback loop to develop a control mask for the laser excitation. The resulting unit can perform complex real-time patterning of laser stimulation, and can be added on to experiments in neuroscience with some adaptation to native equipment.
Issue Date:2014-05
Date Available in IDEALS:2015-10-30

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