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Title:The early history and emergence of molecular functions and modular scale-free network behavior
Author(s):Aziz, Muhammad Fayez
Advisor(s):Caetano-Anollés, Gustavo
Contributor(s):Rodriguez-Zas, Sandra Luisa; Bhalerao, Kaustubh; Ma, Jian
Department / Program:Crop Sciences
Discipline:Bioinformatics
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:M.S.
Genre:Thesis
Subject(s):Protein domains
Elementary loop sequences
Bipartite network
Network projections
Evolutionary timeline
Molecular functions
Scale-free dynamics
Modularity
Abstract:The formation of protein structural domains requires that biochemical functions, defined by conserved amino acid sequence motifs, be embedded into a structural scaffold. Here we trace domain history onto a bipartite network of elementary functional loop (EFL) sequences and domain structures defined at the fold superfamily (FSF) level of Structural Classification of Proteins (SCOP). The resulting ‘elementary functionome’ network and its EFL and FSF graph projections unfold evolutionary ‘waterfalls’ describing emergence of primordial functions. Waterfalls reveal how ancient EFLs are shared by FSF structures in two initial waves of functional innovation that involve founder ‘p-loop’ and ‘winged helix’ domain structures. They also uncover a dynamics of modular motif embedding in domain structures that is ongoing, which transfers ‘preferential’ cooption properties of ancient EFLs to emerging FSFs. Remarkably, we find that the emergence of molecular functions induces hierarchical modularity and power law behavior in network evolution as the networks of motifs and structures expand metabolic pathways and translation.
Issue Date:2015-12-03
Type:Thesis
URI:http://hdl.handle.net/2142/89192
Rights Information:Copyright 2015 Muhammad Fayez Aziz. Materials in this document (all chapters, including the abstract) are reprinted, with permission, from Aziz MF, Caetano-Anollés K and Caetano-Anollés G, 2015, “The early history and emergence of molecular functions and modular scale-free network behavior,” manuscript submitted
Date Available in IDEALS:2016-03-02
Date Deposited:2015-12


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