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Title:Swept Source Optical Coherence Tomography Imaging of the Middle Ear Cavity
Author(s):Duan, Xiangyun J.
Contributor(s):Boppart, Stephen
Subject(s):biomedical optical imaging
medical diagnostic imaging
Abstract:Otitis media (OM), a bacterial infection of the middle ear, is a common pediatric disease. Chronic and recurrent OM is often treated with the surgical placement of tympanostomy tubes in the tympanic membrane (TM), which is the most common reason for pediatric surgery and anesthesia. Antibiotic treatment for chronic OM (COM) is often ineffective, which is explained by the hypothesis that OM is a biofilm-related disease. Recent studies in humans and animals have accumulated evidence for biofilm growth on the middle ear mucosa in COM. However, these studies have required invasive methods to obtain middle ear mucosa samples. Optical Coherence Tomography (OCT) has been used to noninvasively show that OM is associated with biofilm growth on the TM. However, this technique has not yet been used to corroborate physical evidence for mucosal biofilms and imaging has been limited to the interior surface of the tympanic membrane. In this study, we document Swept Source Optical Coherence Tomography (SS-OCT), a variant of the original OCT design (time domain OCT), as a potential method to concurrently image the tympanic membrane and the middle ear medial wall. The capabilities of SS-OCT discussed in this study have potential to enable a more detailed study of biofilm growth in the middle ear under OM conditions. Future studies may enable a deeper understanding of how biofilm develops in OM, as well as a potentially more robust prognosis of long-term outcomes in the presence of acute OM. In addition, discussion is provided for associations between SS-OCT, tympanometry, and Middle Ear Power Analysis (MEPA), two acoustic immitance-based clinical tools, with regards to diagnostic utility.
Issue Date:2016-05
Date Available in IDEALS:2016-06-29

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