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Title:Raman spectroscopic analysis of fatty acids in tumor micro- and macroenvironments in breast cancer
Author(s):You, Sixian
Department / Program:Bioengineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):Raman spectroscopy
Breast cancer
Abstract:Fatty acids play essential roles in the growth and metastasis of cancer cells. To facilitate their avid growth and proliferation, cancer cells not only alter the fatty acid synthesis and metabolism intracellularly and extracellularly, but also in the macroenvironment via direct and indirect pathways. This thesis reports that by using Raman micro-spectroscopy, an increase in the production of polyunsaturated fatty acids (PUFAs) was identified in both cancerous and normal appearing breast tissue obtained from breast cancer patients and tumor-bearing rats. By minimizing confounding effects from mixed chemicals and optimizing the signal-to-noise ratio of Raman spectra, a large-scale transition from monounsaturated fatty acids to PUFAs was observed in the tumor while only a small subset of fatty acids transitioned to PUFAs in the tumor micro- and macroenvironment. These findings demonstrate the power of this spectroscopic analysis, and may provide new insights into the macroenvironmental regulations in breast cancer.
Issue Date:2015-12-07
Rights Information:Copy right 2015 Sixian You
Date Available in IDEALS:2016-07-07
Date Deposited:2016-05

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