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Title:Structural expression of exo-anomeric effect
Author(s):Alonso, E.R.
Contributor(s):Alonso, José L.; Cabezas, Carlos; Peña, Isabel
Subject(s):Structure determination
Abstract:Structural signatures for exo--anomeric effect have been extracted from the archetypal methyl--$\beta$--D--xyloside using broadband Fourier transform microwave spectroscopy combined with laser ablation. Spectrum analysis allows the determination of a set of rotational constants, which has been unequivocally attributed to conformer cc--$\beta$-$^{4}$C$_{1}$ g-, corresponding to the global minimum of the potential energy surface, where the aglycon residue (CH$_{3}$) orientation contributes towards maximization of the exo-anomeric effect. Further analysis allowed the determination of the r$_{s}$ structure, based on the detection of eleven isotopologues - derived from the presence of six $^{13}$C and five $^{18}$O atoms - observed in their natural abundances. The observed glycosidic C$_{1}$-O$_{1}$ bond length decrease (1.38 \AA) can be interpreted in terms of the exo--anomeric effect. As such, the exo--anomeric effect presents itself as one of the main driving forces controlling the shape of many biologically important oligosaccharides.
Issue Date:2016-06-20
Publisher:International Symposium on Molecular Spectroscopy
Genre:Conference Paper / Presentation
Rights Information:Copyright 2016 by the authors
Date Available in IDEALS:2017-01-26

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