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Title:The chemical and enzymatic synthesis of poly(ADP-ribose)
Author(s):Lambrecht, Michael
Director of Research:Hergenrother, Paul J
Doctoral Committee Chair(s):Hergenrother, Paul J
Doctoral Committee Member(s):Silverman, Scott K; Mitchell, Douglas A; Sarlah, David
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Poly(ADP-ribose)
Total Synthesis
Enzymatic Synthesis
Poly(ADP-ribose) Polymerase
Poly ADP ribose polymerase (PARP)
Poly(ADP-ribose) Glycohydrolase (PARG)
Raptinal
Abstract:Poly(ADP-ribose) synthesis and degradation are important cellular processes associated with the DNA damage response and many other pathways. Traditionally, these processes have been challenging to study due to the heterogeneity associated with the synthesis of poly(ADP-ribose). Discussed here are methods for the synthesis of homogeneous poly(ADP-ribose) as well as the biology that is enabled by these synthetic efforts.
Issue Date:2016-07-06
Type:Thesis
URI:http://hdl.handle.net/2142/92923
Rights Information:Copyright 2016 Michael Lambrecht
Date Available in IDEALS:2016-11-10
Date Deposited:2016-08


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