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Title:Effects of Bile Acids on Adipogenesis
Author(s):Akinrotimi, Oludemilade
Contributor(s):Anakk, Sayeepriyadarshini
Subject(s):Molecular and Cellular Biology
Abstract:Bile acids (BA) are important agents for intestinal digestion of lipids and have also been identified as signaling molecules used to maintain metabolic homeostasis. Loss of nuclear receptors Farnesoid X Receptor (FXR) and Small Heterodimer Partner (SHP), which negatively regulate BA, exhibited reduced body weight compared to wild type mice, even when placed on a high fat diet. Subsequently, high serum levels of bile acids and reduced white adipose tissue are observed in the double knockout (DKO) mice. In order to determine the role bile acids play in this beneficial phenotype, we examined BA effect on fat cell accumulation using the NIH-3t3 L1 cells. In differentiated adipocytes we observe a decrease in lipid droplet size, a marker of fat accumulation, in correlation with increasing amounts of bile acid treatments. This suggests that bile acids may have a protective effect against fat accumulation, which looks promising to treat obesity.
Issue Date:2016
Publisher:Office of Minority Student Affairs
Rights Information:Copyright 2016 Oludemilade Akinrotimi
Date Available in IDEALS:2017-03-21

This item appears in the following Collection(s)

  • TRiO - Vol. 2, no.1 2016
    The TRiO McNair journal is a culmination of research conducted by student scholars and their facutly representatives through the Ronald E. McNair Scholars Program.

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