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Title:Plasticity in the PFC Following 5-7-9 Postnatal Alcohol Exposure Using Exercise as an Intervention
Author(s):Delgado, Ivy Hernandez
Contributor(s):Rhodes, Justin
Abstract:Fetal alcohol spectrum disorder (FASD) is an umbrella term used to describe the wide range of deficits caused by exposure to alcohol in utero. Lack of restraint from conducting a behavior or a psychological process, is often impaired in these individuals (inhibition). One region that is attributed to this lack of inhibition is the medial prefrontal cortex. GABAergic parvalbumin interneurons (PV+) play a role in the inhibition surrounding neurons in the medial prefrontal cortex. Therefore, we hypothesize that alcohol exposed individuals will have less PV+ cells compared to their control counterparts. This study used C57/6J male adolescent mice. These subjects were divided into two groups, alcohol exposure (20% ethanol solution at 5 g/kg) or saline. Behavioral testing occurred between PD72-79. Subjects were tested on the Passive Avoidance task and Rotarod. On 85 PD mice were anesthetized, perfused using saline, and the brains processed using Parvalbumin antibody. Preliminary results show a decrease in PV+ cells in alcohol exposed subjects compared to control groups. Further, alcohol exposed subjects exhibited an increased latency to learn the passive avoidance task. Both the number of PV+ cells and the level of inhibitory control were decreased with prenatal alcohol exposure infer the differences in inhibition between the groups; can be seen by quantity of the PV+ cells in the medial prefrontal cortex. These results show the long term impact prenatal alcohol exposure have on the functioning and anatomy of the medial prefrontal cortex.
Issue Date:2016
Publisher:Office of Minority Student Affairs
Rights Information:Copyright 2016 Ivy Hernandez Delgado
Date Available in IDEALS:2017-03-21

This item appears in the following Collection(s)

  • TRiO - Vol. 2, no.1 2016
    The TRiO McNair journal is a culmination of research conducted by student scholars and their facutly representatives through the Ronald E. McNair Scholars Program.

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