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Title:Elucidating the metabolic and signaling pathways that enable Staphylococcus aureus to overcome host-imposed nutrient starvation
Author(s):Kim, Philip
Contributor(s):Kehl-Fie, Thomas
Subject(s):Immunity
Staphyloccocus
aureus
metals
starvation
Abstract:A growing concern in the health community is the rise of antibiotic-resistant bacteria, such as methicillin and vancomycin-resistant Staphylococcus aureus. Due to this rising threat, it is imperative that we discover new drugs that can combat these drug-resistant strains. Successful pathogens utilize mechanisms that enable them to survive, despite the immune response of the host. By elucidating how S. aureus resists the immune response of the host, we will identify new targets for therapeutic intervention, the disruption of which enhances the efficacy of the immune response. One way the host combats bacteria is by sequestering metals at areas of infection, starving the pathogen for these essential nutrients. This host defense is known as nutritional immunity. To resist starvation, S. aureus utilizes a variety of systems that aid in the fight for nutrients. The mechanisms that pathogens, including S. aureus, utilize to overcome nutritional immunity are not fully understood. In this study, we observed that an inability to secrete a broad- spectrum metallophore reduces the ability of S. aureus to compete with the host for zinc. Additional investigations revealed that that only one out of 16 two-component systems elaborated by S. aureus contribute to resisting metal starvation We also determined that both of the cytochrome oxidases expressed by S. aureus enhance the ability of S. aureus to resist nutritional immunity. In total, these investigations have provided new insight into the bacterial factors that promote resistance to nutritional immunity.
Issue Date:2017
Type:Text
URI:http://hdl.handle.net/2142/96046
Rights Information:Copyright 2017 Philip Kim
Date Available in IDEALS:2017-05-15


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