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Title:Molecular Weight-Dependent Release Profiles In Acid-Labile poly(o-(α-alkyl)vinylbenzyaldehyde) Microcapsules
Author(s):Wang, Edward
Contributor(s):Moore, Jeffrey S.
Drug delivery
release kinetics
polymer science
Abstract:The introduction and development of stimuli responsive polymers have garnered considerable application within the field of drug delivery. These polymers are advantageous due to their capability for controlled release of their payload. Release is regulated mainly through polymer degradation or swelling, however additional tuning can be attained by manipulating the payload itself. Release rates of varying molecular weight FITC-Dex (3, 10, 500, 2000 kDa) were studied within an acid-labile poly(o-(α-alkyl)vinylbenzyaldehyde) microcapsule. These rates were modeled according to the Korsmeyer-Peppas equation to define the n and k-values. It was found that the n-values for 3, 10, 500, 2000 kDa dextran conjugates were 5.8e-3, 0.31, 0.71, and 0.85 respectively. Molecular weights above 500 kDa were sufficient to convert the release kinetics from first order to zero order release. This presents a method to accomplish greater control over release profiles.
Issue Date:2017
Genre:Dissertation / Thesis
Rights Information:Copyright 2017 Jeffrey S. Moore
Date Available in IDEALS:2017-05-16

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