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Title:Stimulated emission from biological materials and novel optical resonators for diagnostic and imaging applications
Author(s):Rivera, Jose A
Director of Research:Eden, J. Gary
Doctoral Committee Chair(s):Eden, J. Gary
Doctoral Committee Member(s):Cunningham, Brian T; Insana, Michael; Carney, P. Scott
Department / Program:Bioengineering
Discipline:Bioengineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):biolasers
optical resonators
biophotonics
biosensors
microlasers
Abstract:The first detailed optical characterization of any biological laser, providing spectral, temporal, threshold, and polarization characteristics for the flavin mononucleotide biomolecular laser, is presented here. In addition, our investigation of natural, bio-engineered, and complex biological laser systems culminates in the discovery of a phycobiliprotein laser, a 30% reduction in threshold energy for fluorescent protein lasers excited by circularly polarized light, and the development of a FRET-based laser using biotin-streptavidin bioconjugates comprising organic dye and gold nanoparticle donor/acceptor configurations. Furthermore, we introduce an optical resonator which can be fabricated from the directed assembly of a particle monolayer and is capable of producing hundreds or thousands of microlasers from a single pump beam. These optical resonators are based on an intra-cavity stabilization scheme which is well-suited for sensitive single-cell refractive index monitoring and intra-cavity in-line holography. Finally, we construct a microlens-stabilized microlaser array, based on a titanium doped sapphire crystal, which enables speckle-free pulsed laser imaging of biological specimens with nanosecond temporal resolution.
Issue Date:2017-04-19
Type:Thesis
URI:http://hdl.handle.net/2142/97588
Rights Information:Copyright 2017 Jose A. Rivera
Date Available in IDEALS:2017-08-10
Date Deposited:2017-05


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