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Title:Selective molecular transport in nanopore systems
Author(s):Decker, Karl Steven
Director of Research:Aksimentiev, Aleksei
Doctoral Committee Chair(s):Selvin, Paul R
Doctoral Committee Member(s):Tajkhorshid, Emad; Stack, John
Department / Program:Physics
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):molecular transport, nanopore, biomolecule, ion current, filtration
Abstract:A detailed characterization of the physics of novel nanopore systems has the potential to revolutionize water filtration, nanofluidics, and biomolecule detection technologies. I give my characterizations of five nanopore systems as my dissertation. First, I present my study of nanopores in polyethylene terephthalate (PET), revealing the mechanism for variance in current rectification based on cation species. Second, I demonstrate the mechanism of selective probe capture in bacterial toxin protein α-hemolysin (aHL) using dielectrophoresis. Third, I introduce the first simulation of molecular artificial water channel pillar[5]arene (PAP) and uncover the mechanics of its water transport and self-aggregation properties. Fourth, I characterize the water permeability and ion rejection of truncated human membrane protein aquaporin-1 (AQP) in simulation. Finally, I present MD simulation of truncated AQP as a voltage-gated ionic diode and as the functional element of a double-membrane ionic pump.
Issue Date:2017-06-02
Rights Information:Copyright 2017 Karl Decker
Date Available in IDEALS:2017-09-29
Date Deposited:2017-08

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