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Title:Manganese-catalyzed intermolecular benzylic c–h amination
Author(s):Sookezian, Anasheh
Advisor(s):White, M. Christina
Department / Program:Chemistry
Discipline:Chemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:M.S.
Genre:Thesis
Subject(s):Amination
Manganese
C–H Activation
Abstract:Reactions that directly install nitrogen into C—H bonds of complex molecules are significant due to their ability to immediately change the chemical and biological properties of a given molecule. While selective intramolecular C—H amination reactions are known, intermolecular C—H amination reactions with high reactivity and selectivity are scarce. Achieving high levels of reactivity while maintaining excellent site-selectivity and functional group tolerance remains an important challenge for intermolecular C—H amination. We report a novel manganese perchlorophthalocyanine catalyst [Mn(ClPc)] for a highly site-selective intermolecular benzylic C—H amination of bioactive molecules and natural products. [Mn(ClPc)] is selective for benzylic C—H bonds over other C—H bond types and selects among multiple benzylic C—H bonds based on their electronic and steric properties.
Issue Date:2017-07-19
Type:Thesis
URI:http://hdl.handle.net/2142/98303
Rights Information:Copyright 2017 Anasheh Sookezian
Date Available in IDEALS:2017-09-29
Date Deposited:2017-08


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