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Title:Cellular decision making at the nanoscale
Author(s):Rahil, Zainab
Advisor(s):Leckband, Deborah
Contributor(s):Ha, Taekjip
Department / Program:Bioengineering
Discipline:Bioengineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:M.S.
Genre:Thesis
Subject(s):cell adhesion
Abstract:The well-established dependence of cell traction forces on the compliance of supporting matrices has been attributed to levels of force exerted on components in focal contacts. Here, use of novel, force-limited nanoscale tension gauges revealed that both force and substrate deformations govern cell decision-making during initial attachment to compliant substrates. We propose a mechanical model consistent with observed behavior. Upon formation of stable cell contacts, bond tension and tether rupture govern cell attachment, spreading, and focal adhesion maturation at force levels on individual receptors predicted by prior studies.
Issue Date:2016-04-29
Type:Thesis
URI:http://hdl.handle.net/2142/98323
Rights Information:Copyright 2017 Zainab Rahil
Date Available in IDEALS:2017-09-29
Date Deposited:2017-08


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