2026-09-21T04:52:15Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/100421 2023-07-11 col_2142_5131 com_2142_5130

Kong, Hyunjoon Kong, Hyunjoon Smith, Cartney 2018-08-14T21:37:14Z 2018-08-14T21:37:14Z 2020-08-15T09:15:30Z 2013-07-15 2013-08 Micro- and nanoparticles are designed to deliver drugs and contrast agents to their target site in a controlled manner. One of the greatest obstacles in the performance of such delivery vehicles is their stability in the presence of serum. Here we investigate a method to stabilize a class of liposomes in which lipid vesicles are modified post- fabrication through surface adsorption and anchoring. We hypothesized that the sequential adsorption of functional units followed by covalent cross-linking of the liposome would provide enhanced stability in the presence of human serum. To investigate this hypothesis, liposomes composed of diyne-containing lipids were assembled and functionalized via chitosan conjugated with a hydrophobic anchor and the magnetic resonance (MR) contrast agent, gadolinium, as a model functionality. This strategy served to stabilize the thermodynamically favorable association between liposome and modified functional chitosan. Furthermore, the chitosan-coated, cross-linked liposomes proved more effective as delivery vehicles of MR contrast agents than uncross-linked liposomes due to the reduced liposome degradation and chitosan desorption. Overall, this study demonstrates a useful method to stabilize a broad class of particles used for systemic delivery of various molecular cargos. Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2015-08-01 The student, Cartney Smith, accepted the attached license on 2013-07-10 at 00:06. The student, Cartney Smith, submitted this Thesis for approval on 2013-07-11 at 12:15. This Thesis was approved for publication on 2013-07-15 at 09:33. application/pdf http://hdl.handle.net/2142/100421 Copyright 2013 Cartney E. Smith Cross-Linkable Lipids Magnetic Resonance Imaging Chitosan Liposome Stabilization of liposomal functional anchors by cross-linkable lipids text text Chemical & Biomolecular Engr Chemical Engineering University of Illinois at Urbana-Champaign Thesis M.S.