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Meng, Ling-Jian Meng, Ling-Jian Abbaszadeh, Shiva Smith, Andrew Stubbins, James F. George, Jonathan 2018-09-04T20:33:44Z 2018-09-04T20:33:44Z 2020-09-05T09:15:26Z 2017-12-21 2018-05 X-ray-activated photodynamic therapy (X-PDT) techniques have gained traction for its potential to impart therapeutic effects at greater depths than possible with traditional photodynamic therapy [1], [2]. Interestingly, the underlying X-PDT process could also generate X-ray fluorescence (XF) with metal-based nanoparticles (NPs) and X-ray luminescence (XL), which could be used to monitor the delivery of PDT agents and the subsequent therapeutic process. This allows the possibility of using X-ray fluorescence (XFCT) and X-ray luminescence computed tomography (XLCT) to monitor the therapeutic delivery during radiation therapy. X-ray Raleigh scattering (XRS) produced by the scattered monochromatic incident X-ray can also be correlated with the data from XFCT/XLCT while X-ray transmission CT (XT CT) could provide structural information. This work demonstrates a proof-of-concept of a XF-XL -XT CT imaging platform that allows for quantitative imaging of the X-ray PDT delivery process through complementary contrast mechanisms, and demonstrates this platform’s ability to image X-PDT nanophosphors, such as Y2O3:Eu3+. This work also attempts to address the limitations of the system—sensitivity, acquisition time, and dosage—by examining how incoming X-ray irradiation schemes affect the X-ray fluorescent and X-ray luminescent yields as well as overall X-ray fluorescent image quality. Results show that choosing an optimized incident X-ray spectrum can maximize fluorescent and luminescent yields as well as improve image quality. This in conjunction with improvements in geometric efficiency through a multi-slit ring of detectors has the potential to bring the multi-modality system into a preclinical setting. Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2020-05-01 The student, Jonathan George, accepted the attached license on 2017-12-20 at 10:01. The student, Jonathan George, submitted this Dissertation for approval on 2017-12-20 at 10:17. This Dissertation was approved for publication on 2017-12-21 at 14:53. DSpace SAF Submission Ingestion Package generated from Vireo submission #11999 on 2018-08-31 at 17:16:32 Made available in DSpace on 2018-09-04T20:33:44Z (GMT). No. of bitstreams: 10 GEORGE-DISSERTATION-2018.pdf: 6211594 bytes, checksum: 0a42ffb5aff3e6b08fc18251fddab9f5 (MD5) Figure1_1_permission.pdf: 123235 bytes, checksum: 10a2127bd727d688361ab1106a75c97a (MD5) Figure1_2_permission.pdf: 188035 bytes, checksum: 33ebfbfb992e92a35a36f84bc73d2d44 (MD5) Figure1_3_permision.pdf: 283844 bytes, checksum: 350f03fc0dcd7980bf60e837a1658934 (MD5) Figure1_4_permission.pdf: 145083 bytes, checksum: 7c336098f1d0c46a1a85c1c666c1a24c (MD5) Figure1_5_permission.pdf: 165935 bytes, checksum: 9fdfec96ce8220b8cc94e5873270d5e8 (MD5) Figure1_6_permission.pdf: 118067 bytes, checksum: 4e45aefb47b24801b00e09ad2e158e2b (MD5) Figure1_7_permission.pdf: 134757 bytes, checksum: 6a431474f4c6932de26d6c1d92d7c657 (MD5) LICENSE.txt: 4212 bytes, checksum: 442b3c8c2ae62ec006c6f14260ad8a97 (MD5) Table1_2_permission.pdf: 131394 bytes, checksum: cdbdb38ebaa0eac498f1f625b982cf6a (MD5) Previous issue date: 2017-12-21 Embargo set by: Seth Robbins for item 107190 Lift date: 2020-09-04T20:34:13Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 107190 Lift date: 2020-09-04T20:37:00Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 107190 Lift date: 2020-09-04T20:42:08Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system U of I Only Restriction Lifted for Item 107190 on 2020-09-05T09:15:26Z. application/pdf http://hdl.handle.net/2142/101107 en Copyright 2017 Jonathan George X-ray Nanoparticle Fluorescence Luminescence Imaging A tri-modality x-ray fluorescence, x-ray luminescence, x-ray transmission computed tomography imaging platform for monitoring and stimulating metal-containing nanoparticles text text Nuclear, Plasma, & Rad Engr Nuclear, Plasma, Radiolgc Engr University of Illinois at Urbana-Champaign Dissertation Ph.D.