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2018-12 Cunningham, Brian T. Kwon, Lydia E. 2019-02-06T19:36:44Z 2019-02-06T19:36:44Z 2018-12-13 Starting with the advent of biosensors in the late 1950s and early 1960s, biosensors have come to play a major role in various aspects of human life, including our environment, food and drink, safety, and health. In particular, the detection of clinically relevant biomarkers for the screening, diagnosing, and monitoring of diseases such as cancer is an important goal in improving the treatment outcome and the quality of life of patients. In this thesis, an overview of biosensors and their applications is followed by a detailed description of how a photonic crystal biosensor platform with the capacity for fluorescence enhancement was combined with an automated multiplexed microfluidic flow system and an automated spot-finding and data generation algorithm for the detection of a cancer biomarker in human serum and plasma. Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2019-02-05 without embargo terms The student, Lydia Kwon, accepted the attached license on 2018-12-12 at 13:04. The student, Lydia Kwon, submitted this Thesis for approval on 2018-12-12 at 18:58. This Thesis was approved for publication on 2018-12-13 at 11:21. DSpace SAF Submission Ingestion Package generated from Vireo submission #13303 on 2019-02-05 at 11:16:12 Made available in DSpace on 2019-02-06T19:36:44Z (GMT). No. of bitstreams: 2 KWON-THESIS-2018.pdf: 4954867 bytes, checksum: 5466f9ed872decf3756e1bf8b122aae0 (MD5) LICENSE.txt: 4207 bytes, checksum: 1fdea7dab4fded6d7ac92f43e917395a (MD5) Previous issue date: 2018-12-13 application/pdf http://hdl.handle.net/2142/102520 en Copyright 2018 Lydia E. Kwon biosensor, biomarker, photonic crystal, cancer, disease, diagnostic, screening, point of care, serum, fluorescence, enhanced fluorescence Biosensor and assay development for the detection of disease biomarkers at the point of care text text Bioengineering Bioengineering University of Illinois at Urbana-Champaign Thesis M.S.