2026-09-22T20:08:56Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/105121 2023-07-11 col_2142_5131 col_2142_5163 com_2142_5130 com_2142_5162 com_2142_234

Pan, Dipanjan Pan, Dipanjan Lu, Yi Smith, Andrew M. Dobrucki, Wawrzyniec L. Schwartz-Duval, Aaron Star 2019-08-23T20:44:21Z 2019-08-23T20:44:21Z 2021-08-24T09:15:20Z 2019-01-02 2019-05 Various biomolecules and cell types have been demonstrated to have the capacity to form plasmonic gold nanoparticles when chloroauric acid (HAuCl4) is introduced.We have demonstrated the capacity and utility of nanoparticles generated from endogenous biomolecules through three examples which can potentially be applied to multitudes of applications (1) Through a point of care reactive gel, acting as a scaffold for ionic gold (Au3+) capable of sensing reductive biomolecules presented in high concentrations during eye injury; (2) The generation of gold nanoparticles intrecellularly for enhanced phenotype observation of the cell combined with therapeutic potential; and (3) A simplistic, single-step means of generating gold nanoparticles functionalized with whole cell membrane which imparts minimal impact on biomolecule integrity. From this body of works we have demonstrated that multitudes of endogenous biomaterials have the capacity to reduce and form nanoparticles by variety of mechanisms which can directly be applied to sensing pathological states, applying therapy, as well as a means for improvement on previous biomimetic theranostics. Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2021-05-01 The student, Aaron Schwartz-Duval, accepted the attached license on 2018-12-14 at 15:30. The student, Aaron Schwartz-Duval, submitted this Dissertation for approval on 2018-12-14 at 15:36. This Dissertation was approved for publication on 2019-01-02 at 11:26. DSpace SAF Submission Ingestion Package generated from Vireo submission #13333 on 2019-08-22 at 16:18:18 Made available in DSpace on 2019-08-23T20:44:21Z (GMT). No. of bitstreams: 3 SCHWARTZ-DUVAL-DISSERTATION-2019.pdf: 8447856 bytes, checksum: 54b93a8422b2cfc636558f09a46e26f8 (MD5) LICENSE.txt: 4217 bytes, checksum: 77f9e0e860ca76a23addc8035c7a53e0 (MD5) PROQUEST_LICENSE.txt: 4563 bytes, checksum: 8a0cb99d31fd30b866103213926ded23 (MD5) Previous issue date: 2019-01-02 Embargo set by: Seth Robbins for item 112240 Lift date: 2021-08-23T20:44:50Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 112240 Lift date: 2021-08-23T20:46:41Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 112240 Lift date: 2021-08-23T20:47:38Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 112240 Lift date: 2021-08-23T20:48:32Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Limited Restriction Lifted for Item 112240 on 2021-08-24T09:15:20Z. application/pdf http://hdl.handle.net/2142/105121 en Copyright 2019 Aaron Schwartz-Duval gold, nanoparticles, biomimetics, biomaterials, theranostics, photothermal ablation Co-opting disease pathology for personalized medicine; utilizing endogenous biomaterials to generate theranostic nanoparticles text text Bioengineering Bioengineering University of Illinois at Urbana-Champaign Dissertation Ph.D.