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oai:www.ideals.illinois.edu:2142/105161 2023-07-11 col_2142_5131 col_2142_16338 com_2142_5130 com_2142_16337 com_2142_14793 com_2142_8903

Kehl-Fie, Thomas E. Kehl-Fie, Thomas E. Imlay, James Kuzminov, Andrei Slauch, James Garcia, Yuritzi M. 2019-08-23T20:44:38Z 2019-08-23T20:44:38Z 2021-08-24T09:15:31Z 2019-04-08 2019-05 Bacterial infections are a leading cause of death worldwide. One disease-causing organism is Staphylococcus aureus. Despite numerous methods used by the host immune system to combat infection, S. aureus is still a major health risk. Recently, the Centers for Disease Control and Prevention and the World Health Organization listed S. aureus as one of the top threats to human health [15, 88]. The elevated threat is due to an increase of antibiotic resistant isolates and continued prevalence in the general community [15, 88], which calls for the development of new therapeutic targets to treat staphylococcal infections. In order to combat S. aureus infections, their disease causing mechanisms need to be better understood. One of the many virulence factors of S. aureus to cause disease are superoxide dismutases (SODs). In S. aureus there are two superoxide dismutases, SodA and SodM. The loss of both SODs during a retro-orbital mouse infection led to a decrease in the ability of S. aureus to cause disease [65]. However, the individual contributions of SodA and SodM to the pathogenesis of S. aureus are not completely understood. In this work I aimed to identify how SodA and SodM provide protection to S. aureus and contribute to combating nutritional immunity. Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2021-05-01 The student, Yuritzi Garcia, accepted the attached license on 2019-04-05 at 13:58. The student, Yuritzi Garcia, submitted this Dissertation for approval on 2019-04-05 at 14:02. This Dissertation was approved for publication on 2019-04-08 at 09:45. DSpace SAF Submission Ingestion Package generated from Vireo submission #13497 on 2019-08-22 at 16:20:44 Made available in DSpace on 2019-08-23T20:44:38Z (GMT). No. of bitstreams: 2 GARCIA-DISSERTATION-2019.pdf: 5157064 bytes, checksum: dd308667549fc93d9e8b24db231cc78f (MD5) LICENSE.txt: 4211 bytes, checksum: 6c46e1f62aff0853faefd2e0af2780f5 (MD5) Previous issue date: 2019-04-08 Embargo set by: Seth Robbins for item 112280 Lift date: 2021-08-23T20:44:50Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 112280 Lift date: 2021-08-23T20:46:41Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 112280 Lift date: 2021-08-23T20:47:38Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 112280 Lift date: 2021-08-23T20:48:32Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Limited Restriction Lifted for Item 112280 on 2021-08-24T09:15:31Z. application/pdf http://hdl.handle.net/2142/105161 en Copyright 2019 Yuritzi Garcia Staphylococcus aureus superoxide dismutase metals Elucidating the contributions of superoxide dismutases to staphylococcus aureus pathogenicity text text Microbiology Microbiology University of Illinois at Urbana-Champaign Dissertation Ph.D.