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Dobrucki, Wawrzyniec L Medina Almora, Denise 2020-10-07T22:50:06Z 2020-10-07T22:50:06Z 2022-10-07T22:50:13Z 2020-07-23 2020-08 Peripheral Arterial Disease (PAD) limits blood flow to the lower extremities, causes functional impairment, and in extreme cases, can lead to amputation. While PAD is widely studied, there is still a large gap between preclinical research and clinical translation. This is due in part to the lack of research standardization in preclinical studies, an inadequate resemblance of the animals’ model to the actual disease in humans, and the complexity of the disease’s mechanisms. In this project, we utilized a type I diabetic mice model to establish a working platform that allows us and other researchers and scientists to standardize the preclinical animal studies of PAD. Within this platform, we will highlight critical physiological events that we term “landmarks.” To define these landmarks, we use a multimodal imaging approach starting with Laser Speckle Contrast Imaging (LSCI) and Power Doppler ultrasound for perfusion (superficial and deep tissue, respectively); followed by fluorescent imaging of hypoxia and imaging both angiogenesis and metabolism using molecular PET probes. Briefly, we found that building such a multimodal imaging approach allows us to understand vascular recovery in a holistic matter. However, most importantly, with this method, we will be able to determine the changes in the “landmarks” following the therapeutic intervention. Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2022-08-01 The student, Denise Medina Almora, accepted the attached license on 2020-07-21 at 14:53. The student, Denise Medina Almora, submitted this Thesis for approval on 2020-07-21 at 15:09. This Thesis was approved for publication on 2020-07-23 at 16:27. DSpace SAF Submission Ingestion Package generated from Vireo submission #15702 on 2020-10-02 at 15:52:11 Made available in DSpace on 2020-10-07T22:50:06Z (GMT). No. of bitstreams: 2 MEDINAALMORA-THESIS-2020.pdf: 4119184 bytes, checksum: 45186e7381d01df0ea84516b53a07f32 (MD5) LICENSE.txt: 4217 bytes, checksum: db7ffd7e15e54126d2b082402bc8a872 (MD5) Previous issue date: 2020-07-23 Embargo set by: Seth Robbins for item 116353 Lift date: 2022-10-07T22:50:13Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Author requested closed access (OA after 2yrs) in Vireo ETD system Limited application/pdf http://hdl.handle.net/2142/108724 en Copyright 2020 by Denise Medina Almora. All rights reserved. peripheral arterial disease, angiogenesis, perfusion, diabetes, imaging, multimodal imaging. Multimodal imaging monitoring of key physiological changes of peripheral arterial disease text Thesis Bioengineering Bioengineering University of Illinois at Urbana-Champaign Thesis M.S.