2026-09-22T09:40:34Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/113238 2023-07-11 col_2142_5131 col_2142_14828 com_2142_5130 com_2142_14827 com_2142_14793 com_2142_8903

Aksimentiev, Aleksei Aksimentiev, Aleksei Grosman, Claudio Shukla, Diwakar Pogorelov, Taras Zhao, Shidi 2022-01-12T22:51:34Z 2022-01-12T22:51:34Z 2024-01-12T22:56:20Z 2021-06-18 2021-08 Ion channels form information processing in living cells by facilitating electrical signals across and along cellular membranes. Applying the same principles to man-made systems requires synthetic ion channels that can alter their conductance in response to various external manipulations. And the modulation of ionic current is a signal for nanopore sensing. Here, several simulation studies focusing on ion channel conductance modulation and nanopore sensing are presented. Specifically, comprehensive research on a designed bio-mimetic channel can lead to the ionic current modulation by removable peptide gating in nanopore (FraC), which has the application in biomedical engineering fields such as recognition amino acid sequence and analysis of amino acids and their post-translational modifications for therapeutic purposes. The all-atom simulation models of studying ABA copolymer gating mechanism and a mechanosensitive channel (MscL) gated by thermo-mechanical sensitive ABA copolymer membrane. These works represent potential applications of drug delivery engineering. The nanopore sequencing system by using various mutant CsgG to sense different DNA sequences. Several factors affect the ionic current in nanopore channels, including the shape of the channel, the different DNA nucleotides’ packing geometry, the electroosmotic flow (EOF) in nanopores. These works represent potential applications of improving nanopore sequencing distinguishability. Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-08-01 The student, Shidi Zhao, accepted the attached license on 2021-05-25 at 23:07. The student, Shidi Zhao, submitted this Dissertation for approval on 2021-05-25 at 23:14. This Dissertation was approved for publication on 2021-06-18 at 10:48. DSpace SAF Submission Ingestion Package generated from Vireo submission #16636 on 2022-01-12 at 13:02:53 Made available in DSpace on 2022-01-12T22:51:34Z (GMT). No. of bitstreams: 3 ZHAO-DISSERTATION-2021.pdf: 54665236 bytes, checksum: 51b44e20bd941dfcc216a450f961d75e (MD5) LICENSE.txt: 4207 bytes, checksum: f7d8ec4c8d0cd22d7fe976f01a74471e (MD5) PROQUEST_LICENSE.txt: 4553 bytes, checksum: 8f426b3bee5e132ea5600afc8784538c (MD5) Previous issue date: 2021-06-18 Embargo set by: Seth Robbins for item 121164 Lift date: 2024-01-12T22:51:46Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 121164 Lift date: 2024-01-12T22:53:32Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 121164 Lift date: 2024-01-12T22:54:14Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 121164 Lift date: 2024-01-12T22:55:09Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 121164 Lift date: 2024-01-12T22:56:20Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Author requested closed access (OA after 2yrs) in Vireo ETD system Limited application/pdf http://hdl.handle.net/2142/113238 en Copyright 2021 Shidi Zhao ion channels, MD simulation Ion current modulation in bio-mimetic channel systems text Thesis School of Molecular & Cell Bio Biophysics & Quant Biology University of Illinois at Urbana-Champaign Dissertation Ph.D.