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oai:www.ideals.illinois.edu:2142/113249 2025-06-04 col_2142_5131 col_2142_5163 com_2142_5130 com_2142_5162 com_2142_234

Meng, Ling-Jian Meng, Ling-Jian Insana, Michael Dobrucki, Wawrzyniec La Rivière, Patrick J Tai, Yuan-Chuan Zannoni, Elena Maria 2022-01-12T22:51:37Z 2022-01-12T22:51:37Z 2024-01-12T22:56:20Z 2021-06-21 2021-08 Single photon emission computed tomography (SPECT) is a routine molecular imaging modality, widely appreciated in any nuclear medicine department and clinically used for more than 50 years. Whereas SPECT instrumentation used in clinical and preclinical practice is still mainly based on cumbersome scintillation detectors, characterized by poor energy and spatial resolution, the demand of high-performance SPECT instrumentation continues to rise. We have designed and fully developed the second-generation of a Magnetic Resonance (MR)-Compatible SPECT system, the MRC-SPECT-II system, a high-performance SPECT scanner designed for preclinical imaging applications. The stationary system consists of a full ring of compact semiconductor detectors coupled with a complex collimator aperture, to be integrated inside small-bore pre-clinical MRI scanners. The system is based on two key features: a small-pixel ultra-high resolution solid-state detector module and an innovative geometry named Synthetic Compound-Eye gamma camera, bioinspired to compound eyes often found as vision system in small invertebrates. Preliminary studies demonstrate that the proposed system offers an unprecedented spectroscopic performance (1.71 ± 0.28 keV at 122 keV) in a broad energy range, making it well-suited for multi-isotope SPECT imaging and hyperspectral imaging applications. The prototype achieves a peak geometrical sensitivity of ~0.33%, consistently greater than 0.25% across the central field-of-view of 3.5 cm D × 2.5 cm L. From imaging reconstruction, the prototype offers sub-1-mm spatial resolution when used as standalone SPECT system. To demonstrate that the combination of ultrahigh-resolution imaging spectrometers and the Synthetic Compound-Eye gamma camera design would greatly benefit future clinical SPECT imaging systems, we present the conceptual design study of a brain SPECT imaging system. We prove that the novel system design coupled with non-conventional aperture designs, namely micro-slits and micro-rings, could provide an excellent spatial resolution (<4 mm), a very high sensitivity (up to 1.38%), and a rich angular sampling without scanning motion over a clinically relevant field-of-view of 20 cm in diameter. Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-08-01 The student, Elena Maria Zannoni, accepted the attached license on 2021-06-15 at 20:01. The student, Elena Maria Zannoni, submitted this Dissertation for approval on 2021-06-15 at 20:16. This Dissertation was approved for publication on 2021-06-21 at 10:03. DSpace SAF Submission Ingestion Package generated from Vireo submission #16691 on 2022-01-12 at 13:03:17 Made available in DSpace on 2022-01-12T22:51:37Z (GMT). No. of bitstreams: 4 ZANNONI-DISSERTATION-2021.pdf: 42136845 bytes, checksum: 31a8cda48d93c227c2def6c602fdfd52 (MD5) LICENSE.txt: 4216 bytes, checksum: e88596fe376b807db6b662fffdf14285 (MD5) figure1_4.pdf: 120310 bytes, checksum: 52cca0a670859835d8993eadc9789bf6 (MD5) paper.pdf: 92047 bytes, checksum: 2b545a0d17fdd41298309506477f189b (MD5) Previous issue date: 2021-06-21 Embargo set by: Seth Robbins for item 121175 Lift date: 2024-01-12T22:51:46Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 121175 Lift date: 2024-01-12T22:53:32Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 121175 Lift date: 2024-01-12T22:54:14Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 121175 Lift date: 2024-01-12T22:55:09Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 121175 Lift date: 2024-01-12T22:56:20Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Author requested closed access (OA after 2yrs) in Vireo ETD system Limited application/pdf http://hdl.handle.net/2142/113249 en Copyright 2021 Elena Maria Zannoni semiconductor detector imaging system development nuclear imaging hyperspectral imaging SPECT/MRI Development of the MRC-SPECT-II system: a MR-compatible small-animal SPECT system based on semiconductor imaging spectrometers and a Synthetic Compound-Eye gamma camera design text Thesis Bioengineering Bioengineering University of Illinois at Urbana-Champaign Dissertation Ph.D.