2026-09-19T10:23:29Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/113344 2023-07-11 col_2142_5131 col_2142_16278 com_2142_5130 com_2142_16277 com_2142_9614

Khan, Naiman A Kim, Jeongwoon 2022-01-12T22:56:14Z 2022-01-12T22:56:14Z 2024-01-12T22:56:20Z 2021-07-21 2021-08 Despite the developments in medicine and technology, regular engagement in exercise and healthy eating remains one of the most efficacious lifestyle approaches to maintaining healthy function. The benefits of which extend into cognitive function. However, the mechanism through which exercise and eating habits affects cognitive function is poorly understood. This is a significant obstacle in developing effective intervention strategies to optimize cognitive function using lifestyle approaches. The research presented herein sought to explore the relationship between peripheral blood markers, muscular strength, relational memory and, executive function and neuroelectric indices. Adults between the ages 40-64 completed venous blood draws to examine the molecule of interest, Cathepsin B (CTSB), maximal strength testing to assess isokinetic strength using a Biodex dynamometer (Biodex System 3, Shirley, NY), and a Spatial Reconstruction Task to assess relational memory. Attentional inhibition, a component of executive function, was assessed using a modified Flanker task. Neuroelectric function was assess using event-related brain potentials (ERPs). Specifically, the mean amplitude and peak latency of the P3 waveform in a central-parietal region of interest (ROI) was used to index inhibitory resources and processing speed respectively. After adjusting for possibly confounding variables based on an a priori hypothesis, CTSB was found to be a negative predictor of reaction time for the congruent (β = -0.44, P ≤ 0.01) and incongruent (β = -0.45, P ≤ 0.01) conditions. These results indicate individuals with greater levels of CTSB responded faster. Similarly, isokinetic strength was also found to negatively predict reaction time across both congruent (β = -0.83, P ≤ 0.01) and incongruent (β = -0.80, P ≤ 0.01) conditions. Thus, stronger individuals responded faster. Interestingly, results showed CTSB and isokinetic strength to independently predict reaction time across either condition. These findings lend support to the idea that CTSB may influence cognitive function in a manner that is independent of strength. Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-08-01 The student, Jeongwoon Kim, accepted the attached license on 2021-07-21 at 09:52. The student, Jeongwoon Kim, submitted this Thesis for approval on 2021-07-21 at 10:16. This Thesis was approved for publication on 2021-07-21 at 16:38. DSpace SAF Submission Ingestion Package generated from Vireo submission #17042 on 2022-01-12 at 13:05:26 Made available in DSpace on 2022-01-12T22:56:14Z (GMT). No. of bitstreams: 3 KIM-THESIS-2021.pdf: 11765616 bytes, checksum: 2f9f72df376ccf2a20ed88bb49963902 (MD5) JeongwoonKim_675708333_KCH_Thesis.docx: 11615740 bytes, checksum: ad95ce9068ac1ce765cd4e4e6a4f3386 (MD5) LICENSE.txt: 4205 bytes, checksum: 804e7a46d4dc4257d7380b2609d4a2b2 (MD5) Previous issue date: 2021-07-21 Embargo set by: Seth Robbins for item 121273 Lift date: 2024-01-12T22:56:20Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Author requested closed access (OA after 2yrs) in Vireo ETD system Limited application/pdf http://hdl.handle.net/2142/113344 en Copyright 2021 Jeongwoon Kim Physical fitness Cognition Muscular strength CTSB Independent predictors of executive function: Cathepsin B and strength text Thesis Kinesiology & Community Health Kinesiology University of Illinois at Urbana-Champaign Thesis M.S.