2026-09-21T15:40:38Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/113347 2023-07-11 col_2142_5131 col_2142_14787 com_2142_5130 com_2142_9630 com_2142_234

Aluru, Narayana Rao Dronadula, Mohan Teja 2022-01-12T22:56:15Z 2022-01-12T22:56:15Z 2024-01-12T22:56:20Z 2021-07-22 2021-08 Phospholipids are an important class of lipids which are widely used as model platforms to study biological processes and interactions. They have been known to form stable interfaces with solid substrates like graphene, and these interfaces have potential applications in bio-sensing and targeted drug-delivery. In this paper, we perform molecular dynamics simulations of graphene supported lipid monolayers to characterize lipid properties in such interfaces. We observed substantial differences in lipid properties like tail order-parameter, density profile, diffusion rate, etc., between lipids in a supported monolayer and free-standing bilayer. Further, we studied these interfaces on sinusoidally deformed graphene substrates to understand the effect of curvature on the supported lipids. Here, we observed that the nature of substrate curvature—concave, convex or flat—can affect the lipid/substrate adhesion strength as well as induce structural and dynamical changes in the adsorbed lipid monolayer. Together, these results help characterize the properties of lipid/graphene interfaces, as well as understand the effect of substrate curvature on these interfaces, which can enable tuning of lipid properties for various sensor device and drug delivery applications. Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-08-01 The student, Mohan Teja Dronadula, accepted the attached license on 2021-07-21 at 14:29. The student, Mohan Teja Dronadula, submitted this Thesis for approval on 2021-07-21 at 14:57. This Thesis was approved for publication on 2021-07-22 at 16:43. DSpace SAF Submission Ingestion Package generated from Vireo submission #17054 on 2022-01-12 at 13:05:30 Made available in DSpace on 2022-01-12T22:56:15Z (GMT). No. of bitstreams: 3 DRONADULA-THESIS-2021.pdf: 1948565 bytes, checksum: 5087e5848fb8612628d28fc2de7bc3dd (MD5) dronadula-MS-thesis.docx: 4956096 bytes, checksum: f03a5c9491b8e989cd7eb22f7e3afe5b (MD5) LICENSE.txt: 4217 bytes, checksum: 695bf28435a2a4b6cf0fb67a5b306ed1 (MD5) Previous issue date: 2021-07-22 Embargo set by: Seth Robbins for item 121276 Lift date: 2024-01-12T22:56:20Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Author requested closed access (OA after 2yrs) in Vireo ETD system Limited application/pdf http://hdl.handle.net/2142/113347 en Copyright 2021 Mohan Teja Dronadula molecular dynamics phospholipids graphene supported lipid monolayers biosensors soft matter. Study of Phospholipid/Graphene interfaces and the effect of substrate curvature on lipid morphology and dynamics. text Thesis Mechanical Sci & Engineering Mechanical Engineering University of Illinois at Urbana-Champaign Thesis M.S.