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        <datestamp>2023-07-11</datestamp>
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          <dc:contributor>Shi, Humphrey</dc:contributor>
          <dc:contributor>Shi, Humphrey</dc:contributor>
          <dc:contributor>Allan Hasegawa-Johnson, Mark</dc:contributor>
          <dc:contributor>Liang, Zhi-Pei</dc:contributor>
          <dc:contributor>Sun, Shanhui</dc:contributor>
          <dc:date>2022-05</dc:date>
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          <dc:description>Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms</dc:description>
          <dc:description>The student, Hanchao Yu, accepted the attached license on 2022-02-24 at 17:37.</dc:description>
          <dc:description>The student, Hanchao Yu, submitted this Dissertation for approval on 2022-02-24 at 17:48.</dc:description>
          <dc:description>This Dissertation was approved for publication on 2022-02-25 at 10:10.</dc:description>
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          <dc:title>Accurate and efficient cardiac motion estimation</dc:title>
          <dc:creator>Yu, Hanchao</dc:creator>
          <dc:date>2022-02-25</dc:date>
          <dc:subject>cardiac motion estimation</dc:subject>
          <dc:subject>optical flow</dc:subject>
          <dc:subject>cardiac MR</dc:subject>
          <dc:description>Cardiac motion estimation plays a key role in MRI cardiac feature tracking and function assessment such as myocardium strain. Recent research shows promising results with deep learning-based methods. However, in clinical deployment, previous methods suffer from several issues: (a) Significant performance drops due to mismatched distributions between training and testing datasets, commonly encountered in the clinical environment. It is difficult to collect all representative datasets and to train a universal tracker before deployment. (b) The searching space is large and the optimal is not unique due to the lack of ground truth motion field. (c) Existing deep learning-based methods are 2D models while the cardiac motion is 3D. In this thesis, we proposed a series of approaches to improve the efficiency and accuracy of cardiac motion estimation, along with new evaluation metrics: (a) We propose motion pyramid networks (MPN), a novel deep learning-based approach for accurate and efficient cardiac motion estimation. We predict and fuse a pyramid of motion fields from multiple scales of feature representations to generate a refined motion field. Progress motion compensation is proposed to improve the accuracy through multiple inferences. We then use a novel cyclic teacher-student training strategy to learn the compensation in a single inference step. New evaluation metrics are also proposed to represent errors in a clinically meaningful manner. (b) On top of MPN, we extend it to a novel model for 3D cardiac motion estimation. (c) We proposed a novel fast online adaptive learning (FOAL) framework for better performance on unseen data. It is an online gradient descent-based optimizer that is optimized by a meta-learner. The meta-learner enables the online optimizer to perform a fast and robust adaptation. Our proposed methods outperform strong baseline models on two public available clinical datasets, evaluated by a variety of metrics. The proposed methods also demonstrate time efficiency in inference and online adaptation.</dc:description>
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          <dc:language>eng</dc:language>
          <dc:identifier>https://hdl.handle.net/2142/115340</dc:identifier>
          <dc:rights>Copyright 2022 Hanchao Yu</dc:rights>
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            <name>Ph.D.</name>
            <level>Dissertation</level>
            <discipline>Electrical &amp; Computer Engr</discipline>
            <grantor>University of Illinois at Urbana-Champaign</grantor>
            <department>Electrical &amp; Computer Eng</department>
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