2026-09-20T23:15:42Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/115699 2023-07-11 col_2142_5131 col_2142_8859 com_2142_5130 com_2142_8858 com_2142_234

Aksimentiev, Aleksei Tajkhorshid, Emad Luthey-Schulten, Zaida Ann Sing, Charles E. 2022-05 application/pdf en text Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01 The student, Han-Yi Chou, accepted the attached license on 2022-04-14 at 10:31. The student, Han-Yi Chou, submitted this Dissertation for approval on 2022-04-14 at 11:08. This Dissertation was approved for publication on 2022-04-15 at 09:12. DSpace SAF Submission Ingestion Package generated from Vireo submission #17668 on 2022-11-11 at 12:19:13 Modeling and simulation of intrinsically disordered biomolecular systems Chou, Han-Yi 2022-04-15 coarse-grained simulation molecular dynamics simulation liquid-liquid phase separation percolation transition nuclear pore complex single-stranded binding protein. The conventional sequence-structure-functionality paradigm relates the molecular structures uniquely to the biological functionalities. Recently, this paradigm has been complemented by a new perspective as overwhelming experimental evidence reveals the significant roles of intrinsically disordered molecules in multiple biological functions. Despite of advancement in modern laboratory equipments and techniques, simulation and theoretical modeling remain valuable and serve as complementary tools for they are able to probe into details and to provide explanations for experimental observations. In this dissertation, simulation and modeling were combined to investigate intrinsically disordered molecules in various biological systems. Our research provides detailed descriptions and theoretical models for multiple intrinsically disordered molecules which are vital in cellular functions. Thesis eng https://hdl.handle.net/2142/115699 Copyright 2022 Han-Yi Chou Ph.D. Dissertation Physics University of Illinois at Urbana-Champaign Physics