2026-09-21T14:43:42Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/115857 2023-07-11 col_2142_5131 col_2142_13007 com_2142_5130 com_2142_13006

Barbey, Aron Barbey, Aron Khan, Naiman Mudar, Raksha Wszalek, Tracey 2022-08 application/pdf en text Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01 The student, Kelly Hewes, accepted the attached license on 2022-04-22 at 13:32. The student, Kelly Hewes, submitted this Dissertation for approval on 2022-04-22 at 13:45. This Dissertation was approved for publication on 2022-04-22 at 16:22. DSpace SAF Submission Ingestion Package generated from Vireo submission #17924 on 2022-11-16 at 10:16:02 Peripheral biomarkers and brain behavior, structure, and function in healthy, aging adults Hewes, Kelly 2022-04-22 Cognitive Neuroscience Nutritional Neuroscience Psychoimmunology The current demographic landscape is shifting toward a population disproportionately comprised of adults over the age of 65-years-old. These changes are occurring at an unprecedented rate and challenging the healthcare system to meet the needs of aging-centered care for more people than ever before. As the brain ages it undergoes changes yielding deficits of varying severity, from cognitive deficits seen in normal aging to functional deficits experienced with pathological aging. Observational and interventional studies suggest peripheral factors could influence challenges arising from normal brain aging, though the results are variable. Two such peripheral factors are nutrition, evidenced by studies in nutritional epidemiology, and inflammation, evidenced by studies in psychoneuroimmunology. The unique and regulated barrier between the periphery and the brain, commonly referred to as the blood-brain barrier, determines which nutrients and inflammation factors gain access to the central nervous tissues. Some nutrients, such as xanthophyll carotenoids, can cross this barrier while markers of inflammation are more regulated, with greater access permitted as the integrity of the barrier declines with age. Because these peripheral biomarkers have access to brain tissue, it is possible that they impact changes in cognitive function associated with brain aging by influencing brain structure, network connectivity, and white matter integrity. As such, these biomarkers are potential targets for intervention studies and precision medicine approaches to ameliorate normal brain aging. The following dissertation expands on how xanthophyll carotenoids and inflammation factors moderate relationships that predict facets of intelligence across imaging modalities, providing converging evidence that these peripheral biomarkers impact human health, aging, and disease. Thesis eng https://hdl.handle.net/2142/115857 Copyright 2022 Kelly Hewes Ph.D. Dissertation Neuroscience University of Illinois at Urbana-Champaign Neuroscience Program