2026-09-22T19:24:12Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/121521 2023-12-13 col_2142_5131 col_2142_14828 com_2142_5130 com_2142_14827 com_2142_14793 com_2142_8903

Tajkhorshid, Emad Tajkhorshid, Emad Fratti, Rutilio Mirica, Liviu Pogorelov, Taras 2023-08 application/pdf en text Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms The student, Andres Arango, accepted the attached license on 2023-07-13 at 10:50. The student, Andres Arango, submitted this Dissertation for approval on 2023-07-13 at 11:11. This Dissertation was approved for publication on 2023-07-14 at 14:24. DSpace SAF Submission Ingestion Package generated from Vireo submission #19676 on 2023-12-04 at 17:02:28 Fusion Proteins Membrane Destabilization Pore Formation Pathology Alzheimer's Disease Fungicides Metabolism Signaling Cancer Plasticizers Endocrine Response In this work we investigations membrane associated molecular pathology via a theoretical and computational approach. This work explores the use of mathematical tools from topology and molecular simulations to study membranes. These systems include amyloid beta, amphotericin, PPAR, CYP2J2, and fusion proteins. For amyloid beta, we investigate membrane destabilization and pore formation responsible for pathology in Alzheimer's disease. We probe biophysical properties of amphotericin to develop more clinically relevant fungicides. For CYP2J2, we study the mechanisms for metabolism and signaling relevant to cancer. In PPAR, the role of plasticizers are scrutinized for endocrine response. In addition, fusion and transport mechanisms are probed in the context of SNARE proteins and their priming partners. Overall, the role of membranes and boundaries are explored in molecular pathology. Text eng https://hdl.handle.net/2142/121521 Copyright 2023 Andres Arango Theoretical and computational investigations of membrane associated molecular pathology Arango, Andres Santiago 2023-07-14 Fusion Mechanisms Transport Mechanisms Snare Proteins Priming Membranes Boundaries Molecular Pathology. Membranes Simulation Topology Molecular Simulations Amyloid Beta Amphotericin Ppar Cyp2j2 Ph.D. Dissertation Biophysics & Quant Biology University of Illinois at Urbana-Champaign School of Molecular & Cell Bio