2026-09-23T03:11:54Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/122053 2024-03-01 col_2142_5131 col_2142_14789 com_2142_5130 com_2142_14788 com_2142_8903

Sarlah, David 2023-12 application/pdf en text Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms The student, Peter Ryffel, accepted the attached license on 2023-12-04 at 11:37. The student, Peter Ryffel, submitted this Thesis for approval on 2023-12-04 at 11:39. This Thesis was approved for publication on 2023-12-05 at 17:19. DSpace SAF Submission Ingestion Package generated from Vireo submission #20126 on 2024-03-01 at 13:15:23 Development and application of a borylative heck reaction and towards the total synthesis of nimbolide Ryffel, Peter Borylative Heck Total Synthesis Methodology 2023-12-05 A borylative Heck reaction was developed that allowed for the facile construction of a variety of bicyclic cores that are central to the structures of terpene natural products. It was discovered that bidentate phosphine mono-oxide ligands were critical to not only the product selectivity of this reaction, but also the diastereoselectivity. Additionally, the reaction was demonstrated in synthetic studies that are currently on going. Finally, a different variant of this borylative Heck reaction that utilized a more oxidized vinyl iodide was developed and is currently being utilized in a synthetic route towards the natural product nimbolide, which has potential as an anti-cancer drug. Text eng https://hdl.handle.net/2142/122053 Copyright 2023 Peter Ryffel M.S. Thesis Chemistry University of Illinois at Urbana-Champaign Chemistry