2026-09-22T01:17:02Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/124508 2026-01-14 col_2142_5131 col_2142_14797 com_2142_5130 com_2142_14796 com_2142_397

Anakk, Sayeepriyadarshini Erdman, Jr., John W Gaskins, H. Rex Nelson, Erik R 2024-05 application/pdf en text Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01 The student, Angela Dean, accepted the attached license on 2024-04-08 at 10:23. The student, Angela Dean, submitted this Dissertation for approval on 2024-04-08 at 10:37. This Dissertation was approved for publication on 2024-04-15 at 15:55. DSpace SAF Submission Ingestion Package generated from Vireo submission #20324 on 2024-09-16 at 00:43:10 Uncovering the role of bile acid signaling in facilitating sex differences during hepatocarcinogenesis and liver metabolism Dean, Angela Elizabeth 2024-04-15 Bile Acids Farnesoid X Receptor Small Heterodimer Partner Estrogen Receptor Hepatocarcinogenesis Sex differences in liver physiology and metabolism have been known for several decades, and many of these differences are attributed to estrogen, androgen, or growth hormone signaling. Here, we focus on sex differences in bile acids, which are known for fat digestion, and their metabolism is orchestrated between the host and the gut microbiota. Bile acid homeostasis is altered during hepatocellular carcinoma (HCC), and therefore, we will examine if they are sex-specific. Bile acid can also signal through receptors and regulate many metabolic processes in the liver. Chapter 1 covers the background of this dissertation, and how nutrients impact bile acid composition and levels is detailed in Chapter 2. A review of sex differences in multiple nuclear receptors along the digestive tract is addressed in Chapter 3. Using a mouse model of bile acid dysregulation that develops cancer, we examine the interactions between bile acids and microbiota in a sex-dependent manner in Chapter 4. Next, we investigate if bile acids can bind to estrogen receptor α and if this interaction between signaling pathways can mediate amino acid metabolism in Chapter 5. Finally, Chapter 6 demonstrates that the endogenous bile acid receptor, FXR, can mediate ductular reaction and heme biosynthesis. These studies show that bile acid homeostasis is complex and controlled by the host and microbiota. Bile acid signaling also controls multiple facets of sex-dependent liver metabolism in physiology and pathology. Text eng https://hdl.handle.net/2142/124508 Copyright 2024 Angela Dean Ph.D. Dissertation Nutritional Sciences University of Illinois at Urbana-Champaign Nutritional Sciences