2026-09-21T02:26:43Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/124586 2026-01-14 col_2142_5131 col_2142_5163 com_2142_5130 com_2142_5162 com_2142_234

Cunningham, Brian T 2024-05 application/pdf en text Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01 The student, Sydney Khemtonglang, accepted the attached license on 2024-04-26 at 12:26. The student, Sydney Khemtonglang, submitted this Thesis for approval on 2024-04-26 at 12:34. This Thesis was approved for publication on 2024-05-01 at 16:19. DSpace SAF Submission Ingestion Package generated from Vireo submission #20658 on 2024-09-16 at 00:44:47 A portable, smartphone-linked, and miniaturized photonic resonator absorption microscope (PRAM MINI) for point-of-care diagnostics Khemtonglang, Sydney 2024-05-01 Photonic Crystals Biosensor Absorption Microscopy Point-of-care Diagnostics Point-of-care testing (POCT) has revolutionized healthcare with its rapid, accurate, and all-in-one diagnostic capabilities. In this work, we report the development and validation of the miniaturized Photonic Resonator Absorption Microscope (PRAM Mini), integrated wirelessly with a smartphone application. PRAM Mini harnesses the unique optical coupling of photonic crystal (PC) guided-mode resonance and gold nanoparticle (AuNP) localized surface plasmon resonance to achieve a significant reduction in reflected PC intensity caused by the localized quenching of the AuNP. As an initial demonstration, PRAM Mini effectively detects SARS-CoV-2 antibodies in clinical samples using a blocking biosensor assay. PRAM Mini offers a compact and cost-effective solution for point-of-care diagnostics with text-book-sized dimensions of 23 cm × 21 cm × 10 cm and a total cost of $2,111.65. Its digital resolution quantification features and smartphone-linked functionality enhance accessibility and usability in diverse healthcare settings. The PRAM Mini is a promising tool for addressing the increasing demand for portable and efficient diagnostic solutions, contributing significantly to improved patient care and healthcare system efficiency. Text eng https://hdl.handle.net/2142/124586 Copyright 2024 Sydney Khemtonglang M.S. Thesis Bioengineering University of Illinois at Urbana-Champaign Bioengineering