2026-09-23T01:38:40Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/125600 2025-02-06 col_2142_5131 col_2142_16508 com_2142_5130 com_2142_16507 com_2142_14793 com_2142_8903

application/pdf en text Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-02-04 without embargo terms The student, Amanda Weiss, accepted the attached license on 2024-07-09 at 19:38. The student, Amanda Weiss, submitted this Dissertation for approval on 2024-07-09 at 19:57. This Dissertation was approved for publication on 2024-07-11 at 18:09. DSpace SAF Submission Ingestion Package generated from Vireo submission #21029 on 2025-02-04 at 21:04:50 Circadian rhythmicity of rat neuroendothelial cells at the blood-brain interface Weiss, Amanda C 2024-07-11 Gillette, Martha U Gillette, Martha U Kong, Hyunjoon Chung, Hee Jung Sweedler, Jonathan V Blood-brain Barrier Circadian Rhythms Blood-brain Interface Blood-brain Barrier Permeability eng The Blood-Brain Interface (BBI) facilitates neurological protection from pathogens, the removal of waste products, brain homeostasis, and the permeation of nutrients and drugs. Its dysfunction contributes to the onset of a variety of neurological diseases, including strokes and dementia. Research has shown that both BBI permeability and human susceptibility to strokes fluctuate according to time of day. However, more in vitro studies are required to isolate the effects of circadian rhythms from the effects of sleep and other confounding factors on BBI permeability. The role of neuroendothelial cells, a key component of the BBI, has also not been fully elucidated. We have determined that barrier tightness and permeability oscillate according to time of day in rat neuroendothelial cells. These findings extended to permeability to the blood clotting factor fibrinogen. We also determined that the addition of Carbachol, a pan-acetylcholine receptor agonist, could shift these rhythms. 2024-08 Thesis https://hdl.handle.net/2142/125600 Copyright 2024 Amanda Weiss Molecular & Integrative Physl Molecular & Integrative Physi University of Illinois at Urbana-Champaign Ph.D. Dissertation