2026-09-21T13:04:06Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/125762 2026-02-03 col_2142_5131 col_2142_14789 com_2142_5130 com_2142_14788 com_2142_8903

application/pdf en text Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01 The student, Maxwell Tetrick, accepted the attached license on 2024-06-26 at 10:02. The student, Maxwell Tetrick, submitted this Dissertation for approval on 2024-06-26 at 10:12. This Dissertation was approved for publication on 2024-06-28 at 12:39. DSpace SAF Submission Ingestion Package generated from Vireo submission #20877 on 2025-02-04 at 21:25:07 Nanoparticle intervention for control of cell migration Tetrick, Maxwell G. 2024-06-28 Murphy, Catherine Murphy, Catherine Chan, Jefferson Rodriguez-Lopez, Joaquin Sweedler, Jonathan Gold Nanoparticles Cell Migration Surface Chemistry Chemotaxis eng Nanoparticles exhibit remarkable physiochemical properties unique from their bulk material counterparts. Nanoparticles, and gold nanoparticles in particular, have drawn much interest for use in biomedical applications. Much of the work in the area of biological-nanoparticle interactions focuses on how changes in nanoparticle properties affect cellular uptake, cytotoxicity, and gene expression. However, it has been shown that nanoparticles can have an indirect impact on cells by changing the local microenvironment, causing a change in cell behavior. It is essential to understand the full spectrum of nanoparticle effects on biological systems to ensure safe future therapeutics. In this work, we will first discuss the basics of AuNP synthesis and the biological applications of AuNPs in Chapter 1; research on the nano-bio interface is detailed, and we explore how nanoparticles can influence biological behavior through indirect interactions with the cellular microenvironment. Chemotaxis and cell migration are discussed as a model system for studying indirect nano-bio interactions. In Chapter 2, we analyze how tuning the surface chemistry of AuNPs to have varying levels of sulfonation affects the adsorption of monocyte chemoattractant protein 1 and downstream disruption of human monocytic cell line THP-1 chemotaxis. Chapter 3 discusses our attempt to deconvolute the chemical and mechanical signaling modalities that control colorectal cancer cell HCT-116 migration. Specifically, we attempt to characterize HCT-116 migratory response to chemical and mechanical modulation of the extracellular matrix by cancer associated fibroblasts. 2024-08 Thesis https://hdl.handle.net/2142/125762 Copyright 2024 Maxwell Tetrick Chemistry Chemistry University of Illinois at Urbana-Champaign Ph.D. Dissertation