2026-09-21T20:54:41Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/16015 2023-07-10 col_2142_5163 col_2142_5131 com_2142_5162 com_2142_234 com_2142_5130

Wheeler, Matthew B. Maki, Aaron J. 2010-05-18T18:56:10Z 2010-05-18T18:56:10Z 2012-05-19T10:00:18Z 2010-05-18T18:56:10Z Trauma, congenital defects, and tumor resections can result in discontinuity bone defects, which are typically treated through bone grafting. Potential limitations, such as donor site morbidity, make the development of synthetic implants with similar success to current techniques an attractive alternative for the repair of these structural defecits. Due to its chemical similarity, porous hydroxyapatite (HA) remains a candidate biomaterial for synthetic bone grafting. This thesis investigates a potential method to improve osteointegration of these hydroxyapatite bone scaffolds, the delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2). The objective of this study is to evaluate the effect of rhBMP-2 addition on scaffold osteointegration and degradation in a porcine animal model. Scaffolds were prepared and inserted into surgically induced defects in the mandibles of Yorkshire pigs in order to compare the addition of rhBMP-2-containg hydroxyapatite scaffolds to empty hydroxyapatite control scaffolds and hydroxyapatite scaffolds with empty gelatin microspheres at 6, 12, 24, and 48 weeks after insertion. Macroscale analysis of bone infiltration and scaffold degradation using micro-computed tomography indicated limited differences in bone and scaffold amounts between treatments. However, on the microscale, significant increases in bone infiltration into scaffold micropores with the rhBMP-2 treatment were observed through histological and scanning electron microscope analysis. In addition, significant degradation of the scaffold due to the physiological environment could be observed. We conclude that addition of rhBMP-2 into a porous hydroxyapatite scaffold may be advantageous to bone ingrowth due to improved osteointegration on the microscale. Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2010-04-29T15:17:58Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Maki_Aaron.doc: 14609920 bytes, checksum: 44721805f0faad3bdcec44ce6d0e240e (MD5) Maki_Aaron.pdf: 1331492 bytes, checksum: de579e130928e8b6370f550a3d7375d9 (MD5) Made available in DSpace on 2010-05-18T18:56:10Z (GMT). No. of bitstreams: 4 Maki_Aaron.pdf: 1331492 bytes, checksum: de579e130928e8b6370f550a3d7375d9 (MD5) Maki_Aaron.doc: 14609920 bytes, checksum: 44721805f0faad3bdcec44ce6d0e240e (MD5) 1_Maki_Aaron.pdf: 1328934 bytes, checksum: 59e0b5ae87cfe1eb49138558cfafdade (MD5) license.txt: 4058 bytes, checksum: 538aa5a842c689d2afdee8a5e3897337 (MD5) Item marked as restricted to the 'Administrator' Group (id=1) by William Ingram (wingram2@illinois.edu) on 2010-05-18T18:56:45Z Item is restricted until 2012-05-18T18:56:42Z Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2012-05-19T10:00:18Z Item was in collections: Theses and Dissertations - Bioengineering (ID: 225) University of Illinois Dissertations and Theses (ID: 204) No. of bitstreams: 4 Maki_Aaron.pdf: 1331492 bytes, checksum: de579e130928e8b6370f550a3d7375d9 (MD5) Maki_Aaron.doc: 14609920 bytes, checksum: 44721805f0faad3bdcec44ce6d0e240e (MD5) 1_Maki_Aaron.pdf: 1328934 bytes, checksum: 59e0b5ae87cfe1eb49138558cfafdade (MD5) license.txt: 4058 bytes, checksum: 538aa5a842c689d2afdee8a5e3897337 (MD5) Item released from any restrictions by Sarah Shreeves (sshreeve@illinois.edu) on 2012-05-19T10:00:18Z http://hdl.handle.net/2142/16015 en Copyright 2010 Aaron Maki Bone tissue engineering growth factors Bone morphogenetic protein (BMP) hydroxyapatite scaffolds Long-term osteointegration of BMP-2 eluting hydroxyapatite scaffolds for bone tissue engineering 2010-5 Bioengineering 1343 Bioengineering 0408 University of Illinois at Urbana-Champaign Thesis M.S. PHD: Bioengineering-UIUC 10KS0408PHD