2026-09-21T21:03:39Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/16169 2023-07-10 col_2142_5131 col_2142_8888 col_2142_8859 com_2142_5130 com_2142_8887 com_2142_234 com_2142_8858

nonlinear optics optical imaging nonlinear interferometric vibrational imaging coherent anti-Stokes Raman scattering breast cancer Nonlinear interferometric vibrational imaging for applications in the study and diagnosis of breast cancer Boppart, Stephen A. Benalcazar, Wladimir A. 2010-05-19T18:39:34Z 2010-05-19T18:39:34Z 2010-05-19T18:39:34Z This thesis deals with the problem of developing a microscopy imaging technique with fast acquisition rates and label-free chemical selectivity for the study of tumor formation and its diagnosis in early stages of development. Spontaneous Raman scattering microscopy studies on human breast pathologies have led to models that characterize normal and cancerous breast tissue. This technique, however, is weak and requires long integration times, making it problematic as a clinical imaging tool. Coherent anti-Stokes Raman scattering (CARS) microscopy can improve the speed of acquisition and is more suitable for imaging, but at the cost of losing spectral information and generating unwanted background. As an advance, this thesis describes the technology of Nonlinear Interferometric Vibrational Imaging (NIVI), a CARS-based technique that uses two engineered femtosecond optical pulses and interferometric detection to retrieve broadband Raman signatures free of background. The performance of this technique is shown in the acquisition of spatial-spectral maps in material samples and mammary tissue. Results were validated by comparison with spontaneous Raman microscopy and bright field images of stained sections of the same tissues. Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2010-04-07T17:59:11Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 5 Wladimir_Benalcazar_figures.pptx: 4359417 bytes, checksum: 5e9e0bb778189b4f0affbdc9c391cb4a (MD5) fundamental.bib: 119650 bytes, checksum: 232cef6bac20f6b96b4627fe796dbb3d (MD5) uiucthesis2009_WB.cls: 17103 bytes, checksum: 1a7838f7c6621ff9aa7a2d7723e574a1 (MD5) Benalcazar_Wladimir.tex: 141507 bytes, checksum: a859edd49272722bdb707501c17786d8 (MD5) Benalcazar-Wladimir.pdf: 1868483 bytes, checksum: 481dc6aaa828116a392f04201cac07a2 (MD5) Made available in DSpace on 2010-05-19T18:39:34Z (GMT). No. of bitstreams: 7 Benalcazar-Wladimir.pdf: 1868483 bytes, checksum: 481dc6aaa828116a392f04201cac07a2 (MD5) Wladimir_Benalcazar_figures.pptx: 4359417 bytes, checksum: 5e9e0bb778189b4f0affbdc9c391cb4a (MD5) fundamental.bib: 119650 bytes, checksum: 232cef6bac20f6b96b4627fe796dbb3d (MD5) uiucthesis2009_WB.cls: 17103 bytes, checksum: 1a7838f7c6621ff9aa7a2d7723e574a1 (MD5) Benalcazar_Wladimir.tex: 141507 bytes, checksum: a859edd49272722bdb707501c17786d8 (MD5) Benalcazar_Wladimir.pdf: 1868483 bytes, checksum: 481dc6aaa828116a392f04201cac07a2 (MD5) license.txt: 4069 bytes, checksum: b15b4a65cbbe4bbfae77f8c17637414b (MD5) http://hdl.handle.net/2142/16169 en Copyright 2010 Wladimir Benalcazar 2010-5 Electrical & Computer Eng 1933 Electrical & Computer Engr 1200 University of Illinois at Urbana-Champaign Thesis M.S. PHD:Electr & Computer Eng-UIUC 10KS1200PHD