2026-09-18T20:42:45Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/16707 2023-07-10 col_2142_5131 col_2142_16405 com_2142_5130 com_2142_16404 com_2142_14833

en Copyright 2010 Fabio Valentini Kitchell, Barbara E. Valentini, Fabio 2010-08-20T17:55:32Z 2010-08-20T17:55:32Z 2010-08-20T17:55:32Z 2010-08 One of the several differences between a normal and a neoplastic cell is that there is a phisiological limit to the number of possible cell replications in the former, whereas it appears to be unlimited in the latter. For this reason, cancer cells are thought to undergo a phenomenon of immortalization. The chromosome extremities contain structurally defined elements called telomeres. In normal somatic cells, each mitotic cycle leads to a reduction of telomere lenght until a critical point is reached. Telomere erosion to this critical lenght presents a signal for the cell to arrest further divisions and to undergo cellular senescence or to activate apoptosis. Telomeres that avoid critical shortening could, theoretically, replicate endlessly, thereby immortalizing the cell. One mechanism to restore telomere lenght is the activation of a specific reverse transcriptase called telomerase. The telomerase is a ribonucleoprotein that contains a 9-base-pair RNA template to rapidly construct telomeric repeats. Upregulation of the telomerase enzyme provides immortalizing capacity to neoplastic cells. Based on the hypothesis that telomerase is a specific marker of neoplastic tissues, the development of methods to detect its activity may represent an accurate, non-invasive diagnostic and prognostic tool. Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2010-07-23T13:41:01Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Valentini_Fabio.pdf.pdf: 475546 bytes, checksum: 97f128044cc8f69f35d40bd352264375 (MD5) Valentini_Fabio.pdf: 475546 bytes, checksum: 97f128044cc8f69f35d40bd352264375 (MD5) Made available in DSpace on 2010-08-20T17:55:32Z (GMT). No. of bitstreams: 5 FV FINAL THESIS MATT.doc: 1177088 bytes, checksum: d5654e6bae2e631437297c8ed239a010 (MD5) Valentini_Fabio.pdf: 475546 bytes, checksum: 97f128044cc8f69f35d40bd352264375 (MD5) Valentini_Fabio.pdf.pdf: 475546 bytes, checksum: 97f128044cc8f69f35d40bd352264375 (MD5) 1_Valentini_Fabio.pdf: 412616 bytes, checksum: 54b60f156d3a43dc196a2bf01004e42f (MD5) license.txt: 4062 bytes, checksum: 835f21ef7d445027ab9973a8d815cf08 (MD5) http://hdl.handle.net/2142/16707 telomere telomerase lymphoma dog Comparison of two different methods to detect telomerase activity in normal and neoplastic lymph nodes in the dog Vet Clinical Medicine 1598 VMS-Veterinary Clinical Medcne 0359 University of Illinois at Urbana-Champaign Thesis M.S. MS:VMS-Vet Clinical Med -UIUC 10KS0359MS