2026-09-22T11:59:07Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/16837 2023-07-10 col_2142_5131 col_2142_11615 com_2142_5130 com_2142_9130 com_2142_8903

Kong, Hyun Joon DeVolder, Ross J. 2010-08-20T17:59:22Z 2010-08-20T17:59:22Z 2010-08-20T17:59:22Z 2010-08 Microparticles encapsulating regenerative medicines have been used in tissue engineering because of their several advantages, including non-invasive drug delivery and controllable drug release rates. However, microparticles implanted in tissue defects are readily displaced by external mechanical forces, decreasing their regenerative efficacy. We hypothesized that a drug-encapsulated colloidal gel formed through colloidal attraction between microparticles would resist displacement at an implant site, and subsequently improve therapeutic efficacy. This hypothesis was examined using a colloidal gel formed from the mixing of negatively charged microgels composed of poly(ethylene glycol) (PEG) microgels and poly(sodium acrylate), and positively charged microgels composed of PEG and poly(vinyl benzyl trimethyl ammonium chloride). The structural strength of the colloidal gel could be tuned with the zeta potential and volumetric ratios of the oppositely charged microgels. Furthermore, the implantation of the colloidal gel, encapsulating vascular endothelial growth factor, significantly increased the vascular density while limiting host inflammation, as compared with the implantation of unary microgel suspensions. This study demonstrates the enhancement in the efficacy of microparticle drug delivery systems by tuning rheological properties of suspensions, which should be useful for the design of a wide array of particulate systems for both tissue engineering and drug delivery. Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2010-07-13T15:52:21Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 MS_Ross DeVolder.docx: 18367920 bytes, checksum: 3ec28d8e1cc012904c15fc581c99c1b2 (MD5) DeVolder_Ross.pdf: 969463 bytes, checksum: 3a48699c4865273b32b2172278a46993 (MD5) Made available in DSpace on 2010-08-20T17:59:22Z (GMT). No. of bitstreams: 6 DeVolder_Ross.pdf: 967534 bytes, checksum: 7e4a61066437b489d7b68d26b05e792b (MD5) 1_DeVolder_Ross.pdf: 969463 bytes, checksum: 3a48699c4865273b32b2172278a46993 (MD5) DeVolder_Ross.doc: 14017536 bytes, checksum: 81ff5de440bd7b78775222c22f4484da (MD5) MS_Ross DeVolder.docx: 18368001 bytes, checksum: ecc48cb9aed75f4e65889b2173f684f6 (MD5) 2_DeVolder_Ross.pdf: 967534 bytes, checksum: 7e4a61066437b489d7b68d26b05e792b (MD5) license.txt: 4063 bytes, checksum: ee1fef7df6266a14f20dbfd597c41cec (MD5) http://hdl.handle.net/2142/16837 en Copyright 2010 Ross J. Devolder angiogenesis hydrogel colloidal gel Three dimensionally flocculated proangiogenic microgels for neovascularization Chemical & Biomolecular Engr 1687 Chemical Engineering 0300 University of Illinois at Urbana-Champaign Thesis M.S. MS:Chemical Engineering -UIUC 10KS0300MS