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Cheng, Jianjun Cheng, Jianjun Braun, Paul V. Lu, Yi Wong, Gerard C.L. Zimmerman, Steven C. Tong, Rong 2010-08-31T20:03:14Z 2010-08-31T20:03:14Z 2012-09-07T16:43:34Z 2010-08-31T20:03:14Z 2010-08 The aim of my Ph. D. thesis is to generalize a method for targeted anti-cancer drug delivery. Hydrophilic polymer-drug conjugates involve complicated synthesis; drug-encapsulated polymeric nanoparticles limit the loading capability of payloads. This thesis introduces the concept of nanoconjugates to overcome difficulties in synthesis and formulation. Drugs with hydroxyl group are able to initiate polyester synthesis in a regio- and chemo- selective way, with the mediation of ligand-tunable Zinc catalyst. Herein, three anti-cancer drugs are presented to demonstrate the high efficiency and selectivity in the method (Chapter 2-4). The obtained particles are stable in salt solution, releasing drugs over weeks in controlled manner. With the conjugation of aptamer, particles are capable to target prostate cancer cells in vitro. These results open the gateway to evaluate the in vivo efficacy of nanoconjugates for target cancer therapy (Chapter 5). Mechanism study of the polymerization leads to the discovery of chemosite selective synthesis of prodrugs with acrylate functional groups. Functional copolymer-drug conjugates will expand the scope of nanoconjugates (Chapter 6). Liposome-aptamer targeting drug delivery vehicle is well studied to achieve reversible cell-specific delivery of non-hydoxyl drugs e.g. cisplatin (Chapter 7). New monomers and polymerization mechanisms are explored for polyester in order to synthesize nanoconjugates with variety on properties (Chapter 8). Initial efforts to apply this type of prodrugs will be focused on the preparation of hydrogels for stem cell research (Chapter 9). Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2010-07-13T21:46:08Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Tong_Rong.doc: 26715648 bytes, checksum: c4610a7ca570af2a113328011ca080af (MD5) Tong_Rong.pdf: 6575364 bytes, checksum: 2c822099a8cf35fb42eed9b54daf5caf (MD5) Made available in DSpace on 2010-08-31T20:03:14Z (GMT). No. of bitstreams: 3 Tong_Rong.pdf: 6575364 bytes, checksum: 2c822099a8cf35fb42eed9b54daf5caf (MD5) 1_Tong_Rong.pdf: 6584393 bytes, checksum: b6309adfb73ac688c646c73316c3011b (MD5) license.txt: 4057 bytes, checksum: 293b428de6cdbf1f7752d70cc69ef168 (MD5) Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by William Ingram (wingram2@illinois.edu) on 2010-08-31T20:04:51Z Item is restricted until 2012-08-31T20:04:44Z Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2012-09-07T16:43:34Z Item was in collections: University of Illinois Dissertations and Theses (ID: 204) Dissertations and Theses - Materials Science and Engineering (ID: 649) No. of bitstreams: 4 1_Tong_Rong.pdf.txt: 375773 bytes, checksum: e9196c180e57792ede4da4a28e09f9f8 (MD5) Tong_Rong.pdf: 6575364 bytes, checksum: 2c822099a8cf35fb42eed9b54daf5caf (MD5) 1_Tong_Rong.pdf: 6584393 bytes, checksum: b6309adfb73ac688c646c73316c3011b (MD5) license.txt: 4057 bytes, checksum: 293b428de6cdbf1f7752d70cc69ef168 (MD5) Item released from any restrictions by Sarah Shreeves (sshreeve@illinois.edu) on 2012-09-07T16:43:34Z http://hdl.handle.net/2142/16988 en Copyright 2010 Rong Tong nanomedicine nanoconjugates nanoparticle polylactide aptamer targeted cancer therapy β-diiminate Zinc O-acylation O-carboxyanhydrides Liposome cisplatin paclitaxel camptothecin doxorubicin Development of polymeric drug delivery vehicles for targeted cancer therapy Materials Science & Engineerng 1919 Materials Science & Engr 0130 University of Illinois at Urbana-Champaign Dissertation Ph.D. PHD:Materials Sci & Engr -UIUC 10KS0130PHD