2026-09-20T03:52:49Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/17054 2023-07-10 col_2142_5131 col_2142_14809 com_2142_5130 com_2142_14808 com_2142_9614

A genome-wide association study (GWAS) is an approach that involves scanning markers across complete sets of DNA, or genomes, of many people to indentify genetic variations associated with a particular disease. A GWAS uses unrelated individuals, and for the purposes of this study, only those who persistently stutter, to identify common genetic variants among these people when contrasted to the general population of matched ethnicity. Eighty-four affected subjects, ages 13 to 70 years, of northern European ancestry and 107 matched controls were investigated to identify replicable candidate genes that influence the risk of individuals to stutter. The results associated 10 significant candidate genes with persistent developmental stuttering. In addition, the pathways in which these genes function to potentially disrupt the fluent production of speech were investigated. Functional significance was found with relevance to three functional categories pertaining to neural development, neural function, and behavior. Many of the genes were also found to be implicated in other known neurological, behavioral, and speech and language disorders. Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2010-06-03T13:33:33Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Kraft_ShellyJo.pdf: 1674221 bytes, checksum: 48caf7afc1d9ddcb594a5e4e25e9f6c0 (MD5) Ambrose, Nicoline G. Cox, Nancy J. Ambrose, Nicoline G. Cox, Nancy J. Yairi, Ehud DeThorne, Laura S. Ceman, Stephanie S. Kraft, Shelly Jo 2010-08-31T20:30:43Z 2010-08-31T20:30:43Z 2012-09-07T16:43:39Z 2010-08-31T20:30:43Z 2010-08 Made available in DSpace on 2010-08-31T20:30:43Z (GMT). No. of bitstreams: 3 Kraft_ShellyJo.pdf: 1674221 bytes, checksum: 48caf7afc1d9ddcb594a5e4e25e9f6c0 (MD5) 1_Kraft_ShellyJo.pdf: 1652229 bytes, checksum: bafe129bf752f6d52905d944dab5c036 (MD5) license.txt: 4060 bytes, checksum: 25321ac8638b26bd0e793c731b2be0c8 (MD5) Item marked as restricted to the 'Administrator' Group (id=1) by William Ingram (wingram2@illinois.edu) on 2010-08-31T20:32:55Z Item is restricted until 2012-08-31T20:32:49Z Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2012-09-07T16:43:39Z Item was in collections: University of Illinois Dissertations and Theses (ID: 204) Dissertations and Theses - Speech and Hearing Science (ID: 685) No. of bitstreams: 4 Kraft_ShellyJo.pdf: 1674221 bytes, checksum: 48caf7afc1d9ddcb594a5e4e25e9f6c0 (MD5) 1_Kraft_ShellyJo.pdf: 1652229 bytes, checksum: bafe129bf752f6d52905d944dab5c036 (MD5) license.txt: 4060 bytes, checksum: 25321ac8638b26bd0e793c731b2be0c8 (MD5) 1_Kraft_ShellyJo.pdf.txt: 151509 bytes, checksum: 38c16520dd2d3f17865cc6e1b780ba8f (MD5) Item released from any restrictions by Sarah Shreeves (sshreeve@illinois.edu) on 2012-09-07T16:43:39Z http://hdl.handle.net/2142/17054 en Copyright 2010 Shelly Jo Kraft Stuttering Genome-wide association study (GWAS) Genetics Genome-wide association study of persistent developmental stuttering Speech & Hearing Science 1679 Speech & Hearing Science 0354 University of Illinois at Urbana-Champaign Dissertation Ph.D. PHD:Speech & Hearing Sci -UIUC 10KS0354PHD