2026-09-21T06:53:35Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/18321 2023-07-10 col_2142_5131 col_2142_8888 com_2142_5130 com_2142_8887 com_2142_234

Popescu, Gabriel Mir, Mustafa A. 2011-01-14T22:46:09Z 2011-01-14T22:46:09Z 2011-01-14T22:46:09Z Blood smear analysis has remained a crucial diagnostic tool for pathologists despite the advent of automatic analyzers such as flow cytometers and impedance counters. Though these current methods have proven to be indispensable tools for physicians and researchers alike, they provide limited information on the detailed morphology of individual cells and merely alert the operator to manually examine a blood smear by raising flags when abnormalities are detected. Here I demonstrate an automatic interferometry based smear analysis technique known as Diffraction Phase Cytometry (DPC), which is capable of providing the same information on red blood cells as is provided by current clinical analyzers, while rendering additional, currently unavailable parameters on the 2D and 3D morphology of individual red blood cells (RBCs). To validate the utility of the technique in a clinical setting, I present a comparison between tests generated from 32 patients by a state-of-the-art clinical impedance counter and DPC. The majority of work presented in this thesis is drawn from two publications: M. Mir et al., Journal of Biomedical Optics, vol. 15 (2), 2010, and M. Mir et al. Optics Express, vol. 17, 2009. Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2010-11-29T19:50:01Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Mir_Mustafa.pdf: 761266 bytes, checksum: fb0c7ee1ef9ec7032b5a373c37719f7f (MD5) Made available in DSpace on 2011-01-14T22:46:09Z (GMT). No. of bitstreams: 2 Mir_Mustafa.pdf: 779392 bytes, checksum: 89495822db998f30daded1b7b1b5ffb5 (MD5) license.txt: 4058 bytes, checksum: d00b5d24886a3d332d5a5d70d9745d6e (MD5) http://hdl.handle.net/2142/18321 en Copyright 2010 Mustafa A. Mir Quantitative Phase Imaging Blood Cytometry Interferometry Single Cell Morphology Quantitative phase imaging for blood cytometry 2010-12 Electrical & Computer Eng 1933 Electrical & Computer Engr 1200 University of Illinois at Urbana-Champaign Thesis M.S. MS:Electr & Computer Eng-UIUC 10KS1200MS