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Beck, Carolyn L. Ralph, Matthew A. 2011-01-14T22:51:38Z 2011-01-14T22:51:38Z 2011-01-14T22:51:38Z In this paper, we discuss the first application of recently developed L1-adaptive control methods for the closed-loop control of anesthesia delivery during surgery. Our initial objective, described herein, is to design controllers that are robust to inter-patient variability, such that patients follow a prespecified Bispectral Index (BIS) profile. The controllers are then evaluated on their ability to reject the disturbances effects on the patients’ BIS trajectory that arise during the course of surgery. The controllers are designed using identification-based models constructed using clinical trial data. Two different L1-adaptive control schemes, a state-feedback scheme and an output-feedback scheme, will be evaluated and compared in terms of tracking performance, amount of anesthesia used, and robustness to interpatient variability. Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2010-12-08T18:14:09Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 4 MRalphThesis.tex: 157513 bytes, checksum: 0c6bacdc9509bc56903139d4e25b387e (MD5) MRalphThesis.tex: 157513 bytes, checksum: 0c6bacdc9509bc56903139d4e25b387e (MD5) apx.tex: 71832 bytes, checksum: 4224fa92953059f4a1f8b84497a6d9df (MD5) Ralph_Matthew.pdf: 2440549 bytes, checksum: ba6d9375ce4f7d24e043e70055ef13f9 (MD5) Made available in DSpace on 2011-01-14T22:51:38Z (GMT). No. of bitstreams: 5 apx.tex: 71832 bytes, checksum: 4224fa92953059f4a1f8b84497a6d9df (MD5) Ralph_Matthew.pdf: 2440259 bytes, checksum: dbd96fd22dbaef09aa9b67747ef17df0 (MD5) license.txt: 4062 bytes, checksum: 02418715fc1ca1c01434a7e37b702bb4 (MD5) MRalphThesis.tex: 157513 bytes, checksum: 0c6bacdc9509bc56903139d4e25b387e (MD5) 1_MRalphThesis.tex: 157513 bytes, checksum: 0c6bacdc9509bc56903139d4e25b387e (MD5) http://hdl.handle.net/2142/18463 en Copyright 2010 Matthew A. Ralph Adaptive Control Anesthesia L1 Adaptive L1-Adaptive Control for Anesthesia Delivery 2010-12 Industrial&Enterprise Sys Eng 1422 Systems & Entrepreneurial Engr 3846 University of Illinois at Urbana-Champaign Thesis M.S. MS:Sys & Entreprnural Eng-UIUC 10KS3846MS