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Prosser, C. Ladd Curtis, Brian A. Mangel, Allen W. 2011-04-13T17:37:41Z 2011-04-13T17:37:41Z 1980 Connor, John A. Connor, John A. Arntzen, Charles J. Sherwood, O. David Control of slow wave frequency in cat small intestinal muscle was investigated with microelectrodes. Exposure of intact muscle or isolated longitudinal muscle to low Ca('2+) saline decreased slow wave frequency with less than a 6 mV change in resting potential. This frequency decline was characterized by a prolongation of the diastolic phase of the slow wave. Raising Ca(,0)('2+) to 2-3 times normal increased slow wave frequency. At Ca(,0)('2+) greater than 4 times normal, the slow wave frequency again decreased. However, this decrease in frequency was characterized by a prolongation of the systolic phase of the waveform. Application of Ca conductance blockers (Co('2+), Mn('2+), D600, verapamil), increasing Mg(,0)('2+) or increasing internal pH decreased slow wave frequency by a prolongation of the diastolic region of the slow wave. Addition of db-cAMP to Krebs saline made hypertonic with sucrose or decreasing internal pH increased slow wave frequency. These results indicate a relationship between internal Ca('2+) and the pacemaker of slow wave frequency. A scheme is proposed to explain that relationship. Submitted by Sarah Shreeves (sshreeve@illinois.edu) on 2011-04-13T17:37:41Z No. of bitstreams: 1 Mangel_Allen.pdf: 14571941 bytes, checksum: 0f3f5efb85f424eeea5b106d6fb97b18 (MD5) Made available in DSpace on 2011-04-13T17:37:41Z (GMT). No. of bitstreams: 1 Mangel_Allen.pdf: 14571941 bytes, checksum: 0f3f5efb85f424eeea5b106d6fb97b18 (MD5) Previous issue date: 1980 http://hdl.handle.net/2142/18820 en Copyright 1980 Allen Wayne Mangel Physiology Cats Animals The effects of alterations in internal Ca levels on cat small intestinal slow waves Dissertation / Thesis text Physiology Physiology University of Illinois at Urbana-Champaign Dissertation Ph.D.