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Pirkle, William H. Selness, Shaun Raj 2011-05-07T12:11:42Z 2011-05-07T12:11:42Z 10000-01-01 1996 Mechanistic investigations of several chiral stationary phases (CSPs) were undertaken. These investigations were carried out in an effort to understand the recognition processes responsible for the observed enantioselectivities on the CSPs of interest. Several spectroscopic and chromatographic approaches were taken to establish working models for the recognition processes involved. Specifically, the spectroscopic ($\sp1$H-NMR) studies focused on the solution state behaviors of several CSP analogs in the presence of the individual enantiomers of suitable analytes. Based on observered chemical shift changes and intra- and intermolecular nuclear Overhauser effects upon complexation, conclusions were made with regard to the validity of the initially proposed chiral recognition mechanisms. The chromatographic studies were derived from a basic understanding of these recognition mechanisms. In one case, the role of CSP rigidity is probed and in another, the importance of selector orientation with respect to the underlying silica support is investigated. Made available in DSpace on 2011-05-07T12:11:42Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9625189.pdf: 3492557 bytes, checksum: c537f5444f72be14dd3f709678e16086 (MD5) Previous issue date: 1996 Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:37:55Z Item is restricted indefinitely. Restriction data tranferred 2014-07-01T11:15:40-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission ETDs are only available to UIUC Users without author permission U of I Only AAI9625189 (UMI)AAI9625189 http://hdl.handle.net/2142/19568 eng Copyright 1996 Selness, Shaun Raj Chemistry, Organic Spectroscopic and chromatographic investigations of chiral recognition processes text Chemistry Chemistry University of Illinois at Urbana-Champaign Dissertation Ph.D.