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Erdman, John W. Larson, Mary Rose 2011-05-07T12:35:47Z 2011-05-07T12:35:47Z 10000-01-01 1995 A large body of literature exists regarding the effects of dietary protein on blood lipids in adult humans and animals; however, little is known of the action that protein source may have on cholesterol levels in infants. The research of this thesis addresses the following questions; (1) do infant formula proteins affect blood lipids in young animals, (2) is there a permanent response of protein consumed during childhood on adult cholesterol metabolism, and (3) what mechanisms mediate the blood lipid response to dietary protein? In a study which examined the effects of varying casein and whey proteins fed to rabbits during post-weaning, it was determined that a diet of 40% casein and 60% whey protein elevated blood lipids compared to consumption of greater proportions of casein (p $<$.05); however, following a cholesterol challenge (0.4%) in adulthood there was no persistent blood lipid response though hepatic cholesterol biosynthesis was elevated in the 40:60-consumers (p $<$.05). Examination of an earlier period in development using the neonatal piglet as a model showed that consumption of increasing proportions of whey protein decreased blood cholesterol concentrations (p $<$.05), and increased weight gain (p $<$.05). 100% casein consumption also decreased hepatic cholesterol biosynthesis (p $<$.05). Furthermore, glucagon and cortisol were possible mediators of the blood and liver responses, as they were also elevated in 100% casein-consumers (p $<$.001). Another experiment fed hydrolyzed soy protein, and casein:whey ratios of 80:20 or 40:60 to neonatal piglets. Soy-fed piglets had significantly lower blood cholesterol levels (p $<$.10), higher HDL:LDL ratios than casein:whey-fed animals (p $<$.10), and decreased body weight (p $<$.10). The association between these findings and a hepatic mechanism could not be clearly defined. In conclusion, blood lipids in young animals are effected by consumption of the infant formula proteins; hydrolyzed soy, casein, and whey. However, the mechanism whereby protein affects cholesterol concentrations remains to be determined. Furthermore, a direct relationship between blood cholesterol levels during childhood and adult risk of atherosclerosis is unclear. Made available in DSpace on 2011-05-07T12:35:47Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9543641.pdf: 5018370 bytes, checksum: aa199c9b9e3006ff92a9b951067abc4a (MD5) Previous issue date: 1995 Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:43:05Z Item is restricted indefinitely. Restriction data tranferred 2014-07-01T11:18:48-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission ETDs are only available to UIUC Users without author permission U of I Only AAI9543641 (UMI)AAI9543641 http://hdl.handle.net/2142/20317 eng Copyright 1995 Larson, Mary Rose Chemistry, Biochemistry Health Sciences, Nutrition The effects of dietary protein source on the development of cholesterol metabolism text Nutritional Sciences Nutritional Sciences University of Illinois at Urbana-Champaign Dissertation Ph.D.