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oai:www.ideals.illinois.edu:2142/20750 2023-07-10 col_2142_5131 col_2142_16456 com_2142_5130 com_2142_689 com_2142_397

Health Sciences, Nutrition Health Sciences, Immunology Klein, Barbara P. Liao, C. Hua 2011-05-07T12:48:11Z 2011-05-07T12:48:11Z 10000-01-01 1993 The objectives of the present study were to investigate the effects of vitamin A deficiency on the onset and progression of systemic lupus erythematosus (SLE), using the murine model, MRL/MPJ-lpr/lpr (MRL/l) mice in comparison with MRL/MP-+/+ (+/+) mice, and to postulate a possible mechanism. In Study I, sixty weanling female four week old MRL/l mice were randomly assigned to either the vitamin A-deficient (A-), A-sufficient (A+), and A-sufficient diet/feed restricted (DR) groups. In Study II fifty-eight same-age and -sex MRL/l mice were randomly assigned to either the A$-$ or A+ groups, while twenty-four +/+ mice, of the same sex and age range as MRL/l, were assigned to the normal control group (+/+ group). The results of both studies showed that vitamin A deficiency had a significant effect on preventing the MRL/l mice body weight loss due to the progression of SLE. Vitamin A deficiency also tended to suppress the abnormal enlargement of the thymus and spleen due to massive proliferation of abnormal T cells in MRL/l mice. The results of in vitro splenocyte proliferation tests indicate that vitamin A deficiency decreased the proportion of abnormal T and hypersecreation B cells so that the normal T and B cell ratio increased and was closer to the +/+ group in MRL/l mice. The results from Study II strongly suggested that the above beneficial effects of vitamin A deficiency were related to an increased expression of interleukin-2 (IL-2) receptor on the surface of the MRL/l mouse splenocytes, which resulted in an increased proliferation of normal T and B cells. To summarize, vitamin A deficiency decreases the overall progression of SLE in MRL/l mice. The mechanism includes an increased activity of suppressor T cells and an increased expression of IL-2 receptors on the surface of the splenocytes. Made available in DSpace on 2011-05-07T12:48:11Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9314904.pdf: 3721577 bytes, checksum: 10e619c55e9f06cb83fbd11b4bc5f232 (MD5) Previous issue date: 1993 Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:46:01Z Item is restricted indefinitely. Restriction data tranferred 2014-07-01T11:20:30-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission ETDs are only available to UIUC Users without author permission U of I Only AAI9314904 (UMI)AAI9314904 http://hdl.handle.net/2142/20750 eng Copyright 1993 Liao, C. Hua Biology, Cell The effects of vitamin A deficiency on the immune system in a murine model of systemic lupus erythematosus text Human and Community Development Human and Community Development University of Illinois at Urbana-Champaign Dissertation Ph.D.