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Pirkle, William H. Bowen, William Edwin 2011-05-07T12:50:34Z 2011-05-07T12:50:34Z 10000-01-01 1994 Systematic investigations of chiral recognition mechanisms have led to chiral selectors which, when immobilized and used as chromatographic stationary phases, show high levels of enantioselectivity. Since these selectors are designed to function in essentially the same manner whether immobilized or in solution, the chromatographic data enable one to quickly evaluate the suitability of a selector for use in hollow-fiber membrane systems. Several chromatographically developed selectors show promise for large scale separation of enantiomers using hollow-fiber membrane technology. Chiral selectors derived from N-(1-naphthyl)leucine have been used in a hollow-fiber membrane system (Sepracor) to separate the enantiomers of amino acid derivatives. Enantiomeric purities exceeding 95% have been obtained in a single pass through the system. For data collection, sample sizes were limited to gram quantities of racemate. However, it is clear that the present system could be used to resolve larger samples and that the continuous (as opposed to batch) process scale separation of enantiomers is feasible by this approach. Made available in DSpace on 2011-05-07T12:50:34Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9503146.pdf: 4517887 bytes, checksum: 656e361c19f39e27a13d60f81131ac05 (MD5) Previous issue date: 1994 Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:46:35Z Item is restricted indefinitely. Restriction data tranferred 2014-07-01T11:20:54-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission ETDs are only available to UIUC Users without author permission U of I Only AAI9503146 (UMI)AAI9503146 http://hdl.handle.net/2142/20831 eng Copyright 1994 Bowen, William Edwin Chemistry, General Chemistry, Analytical Chemistry, Organic Design and utilization of chiral selectors for enantioselective membrane transport text Chemistry Chemistry University of Illinois at Urbana-Champaign Dissertation Ph.D.