2026-09-24T05:00:16Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/20951 2023-07-10 col_2142_5131 col_2142_14835 com_2142_5130 com_2142_14834 com_2142_14833

Jeffery, Elizabeth H. Ahn, Hye-Won 2011-05-07T12:53:59Z 2011-05-07T12:53:59Z 10000-01-01 1994 Fluoride and aluminum, which are known to form a strong complex, are both present in finished drinking water. The effect of F and Al on one another's tissue accumulation was determined using adult, male New-Zealand white rabbits. Fluoride accumulation in plasma, urine, incisors and tibia was increased as the F addition to the drinking water increased within groups receiving a single concentration of Al. In contrast, F accumulation in plasma, urine, incisors and tibia decreased as the Al concentration increased within groups receiving a single F concentration. In addition, Al levels of plasma and tibia were significantly increased by the addition of F to the drinking water, even in animals receiving no Al in their drinking water. Therefore, some of the toxicity associated with high F level might in fact be associated with Al or a combined form of F and Al. Because in vivo studies have shown that F causes the co-accumulation of Al in bone, we determined the interactive effect of these two agents on bone turnover and accumulation in mouse calvarial culture. The combination of F and Al increases alkaline phosphatase activity in calvaria. However, the co-accumulation of Al in bone treated with F that we reported using in an in vivo system could not be confirmed using a calvaria culture system, due to high non-specific adsorption of Al. Further, the effect of Al on F uptake and mutagenicity in Salmonella typhymurium TA98 has been determined and any effect of Al on Ames test results for F was also determined. Intracellular F was below the limit of detection (0.2 ppm). However, F was taken up from media, providing that Al was also present. Neither F, Al, nor Al:F was found to be mutagenic as assessed by a modification of the Ames standard plate incorporation assay. While F did not appear to cause mutations in the presence or absence of Al, it was concluded that the mutagenicity test, using TA98, is not suitable for the evaluation of F mutagenicity. Made available in DSpace on 2011-05-07T12:53:59Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9503125.pdf: 4416922 bytes, checksum: 295468f4f9e0ecc50aa6b646a1f8d8fd (MD5) Previous issue date: 1994 Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:47:28Z Item is restricted indefinitely. Restriction data tranferred 2014-07-01T11:21:26-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission ETDs are only available to UIUC Users without author permission U of I Only AAI9503125 (UMI)AAI9503125 http://hdl.handle.net/2142/20951 eng Copyright 1994 Ahn, Hye-Won Health Sciences, Toxicology Health Sciences, Public Health Environmental Sciences The influence of the interaction of fluoride (F) and aluminum (Al) on bioavailability in bacterial and mammalian systems text Veterinary Biosciences Veterinary Biosciences University of Illinois at Urbana-Champaign Dissertation Ph.D.