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Phillips, George N., Jr., Chacko, Susan 2011-05-07T13:26:11Z 2011-05-07T13:26:11Z 10000-01-01 1991 Motions in proteins are often an important part of their function. Structural information about the protein is hence incomplete without an understanding of the protein dynamics. X-ray crystallography is the technique used in the majority of protein structure determinations; from a crystallographic standpoint as well, the movement of the molecules in the crystal which profoundly affect the X-ray scattering are important. All motions in the crystal affect the Bragg scattering and also give rise to diffuse scattering between and surrounding the Bragg spots. The diffuse X-ray scattering may comprise a large part of the total scattering from the crystal, and it contains information about the correlation of motions that is not available from analysis of the Bragg diffraction peaks. Tropomyosin is a muscle protein that is involved in control of the muscle contraction process. Changes in the structural conformation of the protein are an essential part of this process. Tropomyosin crystals exhibit striking diffuse scattering patterns which are related to its inherent flexibility and motions in the crystal. Diffuse scattering data along all the major directions of the crystal have been measured. A complete three-dimensional diffuse scattering data set has been simulated, and this has been compared to the experimental data in the measured directions. A combination of empirical and analytical methods were used to perform the simulations, and the amplitudes, directions and correlation distances of the motions within the crystal have been calculated. Made available in DSpace on 2011-05-07T13:26:11Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9136564.pdf: 3711670 bytes, checksum: 00f1c04f4d101c748340ba8b70364527 (MD5) Previous issue date: 1991 Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:54:44Z Item is restricted indefinitely. Restriction data tranferred 2014-07-01T11:25:28-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission ETDs are only available to UIUC Users without author permission U of I Only AAI9136564 (UMI)AAI9136564 http://hdl.handle.net/2142/22013 eng Copyright 1991 Chacko, Susan Biophysics, General Diffuse X-ray scattering from tropomyosin crystals text Biophysics Biophysics University of Illinois at Urbana-Champaign Dissertation Ph.D.