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oai:www.ideals.illinois.edu:2142/22808 2023-07-10 col_2142_5131 col_2142_11614 com_2142_5130 com_2142_11613 com_2142_8903

Banich, Marie T. Stolar, Neal Myles 2011-05-07T13:52:09Z 2011-05-07T13:52:09Z 10000-01-01 1992 Most previous attempts to determine the neurophysiological mechanisms associated with schizophrenia have examined schizophrenia as an unitary, or at most a binary (e.g., positive versus negative), entity. This study made use of a system-level approach in which individual symptoms were examined for their relationship to the dysfunction of specific brain regions. Twenty-seven patients with schizophrenia were assessed for severity of alogia, affective flatness, hallucinations, and delusions. Dysfunction of specific brain regions was assessed using neuropsychological tests sensitive to damage of selective brain regions. Of these, the reliable ones used in the analyses were word fluency for left-frontal functioning, design fluency for right-frontal functioning, and digit-sequences recall for left-temporohippocampal functioning. As expected, alogia was associated with left-frontal dysfunction. Unexpectedly, alogia was also associated with right-frontal dysfunction. In addition, as expected, affective flatness was associated with right-frontal dysfunction, but this association was not significantly greater than that of affective flatness with left-temporohippocampal dysfunction. By contrast, hallucinations and delusions were not associated with dysfunction of any of these brain regions. A neuropsychological model is presented to account for two patterns of affective flatness and alogia: their co-occurrence, associated with general frontal dysfunction, and affective flatness occurring without alogia, associated with right-, but not left-, frontal dysfunction. Made available in DSpace on 2011-05-07T13:52:09Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9215887.pdf: 6791761 bytes, checksum: 4dd849c6b222a941ace645b1a6667f63 (MD5) Previous issue date: 1992 Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T15:00:08Z Item is restricted indefinitely. Restriction data tranferred 2014-07-01T11:28:26-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission ETDs are only available to UIUC Users without author permission U of I Only AAI9215887 (UMI)AAI9215887 http://hdl.handle.net/2142/22808 eng Copyright 1992 Stolar, Neal Myles Biology, Neuroscience Psychology, Psychobiology Psychology, Clinical Psychology, Physiological The association of symptoms of schizophrenia and dysfunction of specific brain regions text Psychology Psychology University of Illinois at Urbana-Champaign Dissertation Ph.D.