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oai:www.ideals.illinois.edu:2142/24033 2023-07-10 col_2142_11614 col_2142_5131 com_2142_11613 com_2142_8903 com_2142_5130

Gulley, Joshua M. Venheim, Emily R. 2011-05-25T15:04:38Z 2011-05-25T15:04:38Z 2011-05-25T15:04:38Z 2011-05 Humans exhibit marked individual differences in susceptibility to develop drug dependence. Addiction-like behaviors have been modeled in rodents as well with similar individual variability in the development of addiction-like behaviors. One potential mechanism that could differentiate addiction-vulnerable from addiction-resistant individuals is sensitivity to reward-paired cues. Pavlovian-instrumental transfer (PIT) is a paradigm that assesses the extent to which reward cues can initiate previously unpaired instrumental responding for a common reward. To examine the potential that sensitivity to reward-paired cues is a mechanism differentiating individuals with a propensity to develop addiction-like behaviors, we used a rodent model known to differ in initial responsiveness to cocaine as well as in behaviors implicated in ‘addiction-vulnerability’. We hypothesize that rodents displaying the ‘addiction-vulnerable’ phenotype will initiate instrumental responding to a greater degree when presented with cues associated with reward than their counterparts. Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2011-04-13T18:47:28Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Venheim_Emily.doc: 2157568 bytes, checksum: d65eb13d11f779946288bb4e854df6d9 (MD5) Venheim_Emily.pdf: 354101 bytes, checksum: ff067f5c6486867efb6aa8e2d053d2ad (MD5) Made available in DSpace on 2011-05-25T15:04:38Z (GMT). No. of bitstreams: 3 Venheim_Emily.pdf: 354101 bytes, checksum: ff067f5c6486867efb6aa8e2d053d2ad (MD5) license.txt: 4063 bytes, checksum: 06e1b37e12218d88a434db4b282d05b5 (MD5) Venheim_Emily.doc: 2157568 bytes, checksum: d65eb13d11f779946288bb4e854df6d9 (MD5) http://hdl.handle.net/2142/24033 en Copyright 2011 Emily R. Venheim cocaine individual differences addiction Individual differences in cocaine's locomotor activating effects predicts reward-directed behavior Psychology 1299 Psychology 0338 University of Illinois at Urbana-Champaign Thesis M.A. PHD:Psychology -UIUC 10KS0338PHD